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The effect of brain atrophy on outcome after a large cerebral infarction
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Hyung | - |
dc.contributor.author | Oh, Chang Wan | - |
dc.contributor.author | Han, Jung Ho | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Kwon, O-Ki | - |
dc.contributor.author | Son, Young-Je | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Chung, Young Seob | - |
dc.date.accessioned | 2024-08-08T01:46:45Z | - |
dc.date.available | 2024-08-08T01:46:45Z | - |
dc.date.created | 2021-12-10 | - |
dc.date.created | 2021-12-10 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | Journal of Neurology, Neurosurgery and Psychiatry, Vol.81 No.12, pp.1316-1321 | - |
dc.identifier.issn | 0022-3050 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208063 | - |
dc.description.abstract | Purpose We retrospectively evaluated the effect of brain atrophy on the outcome of patients after a large cerebral infarct. Methods Between June 2003 and Oct 2008, 134 of 2975 patients with stroke were diagnosed as having a large cerebral infarct. The mean age of the patients was 70 (21-95) y. The mean infarct volume was 223.6 +/- 95.2 cm(3) (46.0-491.0). The inter-caudate distance (ICD) was calculated as an indicator of brain atrophy by measuring the hemi-ICD of the intact side and then multiplying by two to account for brain swelling at the infarct site. The mean ICD was 18.0 +/- 4.8 mm (9.6-37.6). Results Forty-nine (36.6%) patients experienced a malignant clinical outcome (MCO) during management in the hospital. Thirty-one (23.1%) patients had a favourable functional outcome (FO) (modified Rankin scale (mRS) <= 3) and 49 (36.6%) had an acceptable functional outcome (AO) (mRS <= 4) at 6 months after stroke onset. In the multivariate analysis, brain atrophy (ICD >= 20 mm) had a significant and independent protective effect on MCO (p-0.003; OR-0.137; 95% CI 0.037 to 0.503). With respect to FO, the age and infarct volume reached statistical significance (p<0.001, OR=0.844, 95% CI 0.781 to 0.913; p=0.006, OR=0.987, 95% CI 0.977 to 0.996, respectively). Brain atrophy (ICD >= 20 mm) was negatively associated only with AO (p=0.022; OR=0.164; 95% CI 0.035 to 0.767). Conclusions Brain atrophy may have an association with clinical outcome after a large stroke by a trend of saving patients from an MCO but also by interfering with their functional recovery. | - |
dc.language | 영어 | - |
dc.publisher | BMJ Publishing Group | - |
dc.title | The effect of brain atrophy on outcome after a large cerebral infarction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1136/jnnp.2009.197335 | - |
dc.citation.journaltitle | Journal of Neurology, Neurosurgery and Psychiatry | - |
dc.identifier.wosid | 000284312200007 | - |
dc.identifier.scopusid | 2-s2.0-78649688867 | - |
dc.citation.endpage | 1321 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 1316 | - |
dc.citation.volume | 81 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Sang Hyung | - |
dc.contributor.affiliatedAuthor | Oh, Chang Wan | - |
dc.contributor.affiliatedAuthor | Kwon, O-Ki | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.contributor.affiliatedAuthor | Han, Moon-Ku | - |
dc.contributor.affiliatedAuthor | Chung, Young Seob | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARTERY TERRITORY INFARCTION | - |
dc.subject.keywordPlus | DECOMPRESSIVE SURGERY | - |
dc.subject.keywordPlus | HEMISPHERIC INFARCTION | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | HEMICRANIECTOMY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADULTS | - |
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