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24-Hydroxyursolic Acid from the Leaves of the Diospyros kaki (Persimmon) Induces Apoptosis by Activation of AMP-activated Protein Kinase
DC Field | Value | Language |
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dc.contributor.author | Khanal, Prem | - |
dc.contributor.author | Oh, Won-Keun | - |
dc.contributor.author | Thuong, Phuong Thien | - |
dc.contributor.author | Cho, Sung Dae | - |
dc.contributor.author | Choi, Hong Seok | - |
dc.date.accessioned | 2024-08-08T01:47:23Z | - |
dc.date.available | 2024-08-08T01:47:23Z | - |
dc.date.created | 2018-02-06 | - |
dc.date.created | 2018-02-06 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | Planta Medica, Vol.76 No.7, pp.689-693 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208146 | - |
dc.description.abstract | There are multiple lines of evidence that persimmon extract and its constituents have potent antitumor activity against human cancer cells. However, the molecular mechanisms of 24-hydroxyursolic acid, a triterpenoid found in persimmon, on antitumor activities are not yet understood. Here, we demonstrate that 24-hydroxyursolic acid inhibited cell proliferation, strongly activated AMP-activated protein kinase (AMPK) and mediated critical anticancer effects by inhibition of cyclooxygenase (COX-2) expression in HT- 29 cells. In addition, 24-hydroxyursolic acid induced cellular apoptosis by activation of poly (ADP-ribose) polymerase (PARP), caspase-3, and phosphorylation of p53 at Ser15. It also strongly induced DNA fragmentation in HT-29 cells and thereby significantly inhibited colony formation of HT-29 cells in soft agar. In addition, 24-hydroxyursolic acid blocked the EGF-induced ERKs phosphorylation and led to the inhibition of AP-1 activity and cell transformation in JB6 CL41 cells. Collectively, these findings are the first to reveal a molecular basis for the anticarcinogenic action of 24-hydroxyursolic acid and might account for the reported chemopreventive and chemotherapic effects of persimmon extracts. | - |
dc.language | 영어 | - |
dc.publisher | Georg Thieme Verlag | - |
dc.title | 24-Hydroxyursolic Acid from the Leaves of the Diospyros kaki (Persimmon) Induces Apoptosis by Activation of AMP-activated Protein Kinase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1055/s-0029-1240678 | - |
dc.citation.journaltitle | Planta Medica | - |
dc.identifier.wosid | 000277659000007 | - |
dc.identifier.scopusid | 2-s2.0-77952088621 | - |
dc.citation.endpage | 693 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 689 | - |
dc.citation.volume | 76 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Won-Keun | - |
dc.contributor.affiliatedAuthor | Cho, Sung Dae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLON-CANCER CELLS | - |
dc.subject.keywordPlus | AP-1 ACTIVITY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordAuthor | Diospyros kaki | - |
dc.subject.keywordAuthor | Ebenaceae | - |
dc.subject.keywordAuthor | persimmon | - |
dc.subject.keywordAuthor | 24-hydroxyursolic acid | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | COX-2 | - |
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