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Association between the-159C/T CD14 gene polymorphism and tuberculosis in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Kang, Young Ae | - |
dc.contributor.author | Lee, Hye Won | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.date.accessioned | 2024-08-08T01:47:42Z | - |
dc.date.available | 2024-08-08T01:47:42Z | - |
dc.date.created | 2023-07-25 | - |
dc.date.created | 2023-07-25 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | FEMS Immunology and Medical Microbiology, Vol.57 No.3, pp.229-235 | - |
dc.identifier.issn | 0928-8244 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208199 | - |
dc.description.abstract | The aim of the present study was to confirm the association between the CD14 -159C/T polymorphism and tuberculosis in the Korean population and to elucidate the functional basis for this putative association. CD14 -159C/T genotypes were determined by PCR - restriction fragment length polymorphism analysis in 274 tuberculosis patients and 422 healthy controls. Recombinant CD14 promoter-luciferase reporter constructs, including the -159T or -159C allele, were transfected into K562 and BEAS-2B cells, and luciferase activities were measured and compared. Levels of serum sCD14 and interferon-gamma secreted by peripheral blood mononuclear cells (PBMCs) were measured using enzyme-linked immunosorbent assay.The frequency of -159TT genotypes was higher in tuberculosis patients than in healthy controls. The promoter activity of the -159T allele was higher than that of the -159C allele. Serum sCD14 levels were higher among tuberculosis patients with -159TT genotypes than among those with -159CC genotypes and interferon-gamma release by PBMCs was decreased in subjects with -159TT genotypes. In conclusion, the -159TT CD14 genotypes were associated with tuberculosis development in Koreans. This association might be a result of the higher promoter activity of the -159T allele, the higher level of sCD14, and the decreased interferon-gamma secretion in subjects with -159TT genotypes. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell | - |
dc.title | Association between the-159C/T CD14 gene polymorphism and tuberculosis in a Korean population | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1574-695X.2009.00602.x | - |
dc.citation.journaltitle | FEMS Immunology and Medical Microbiology | - |
dc.identifier.wosid | 000271466300003 | - |
dc.identifier.scopusid | 2-s2.0-71049187209 | - |
dc.citation.endpage | 235 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 229 | - |
dc.citation.volume | 57 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Han, Sung Koo | - |
dc.contributor.affiliatedAuthor | Shim, Young-Soo | - |
dc.contributor.affiliatedAuthor | Yim, Jae-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | SOLUBLE CD14 | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | RECEPTOR GENE | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | tuberculosis | - |
dc.subject.keywordAuthor | CD14 | - |
dc.subject.keywordAuthor | susceptibility | - |
dc.subject.keywordAuthor | polymorphism | - |
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