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D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, Hubert | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Cava, Felipe | - |
dc.contributor.author | Takacs, Constantin N. | - |
dc.contributor.author | Clardy, Jon | - |
dc.contributor.author | de Pedro, Miguel A. | - |
dc.contributor.author | Waldor, Matthew K. | - |
dc.date.accessioned | 2024-08-08T01:47:49Z | - |
dc.date.available | 2024-08-08T01:47:49Z | - |
dc.date.created | 2018-06-01 | - |
dc.date.created | 2018-06-01 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.citation | Science, Vol.325 No.5947, pp.1552-1555 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208221 | - |
dc.description.abstract | In all known organisms, amino acids are predominantly thought to be synthesized and used as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures. In Vibrio cholerae, a dedicated racemase produced D-Met and D-Leu, whereas Bacillus subtilis generated D-Tyr and D-Phe. These unusual D-amino acids appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. D-Amino acids influenced peptidoglycan composition, amount, and strength, both by means of their incorporation into the polymer and by regulating enzymes that synthesize and modify it. Thus, synthesis of D-amino acids may be a common strategy for bacteria to adapt to changing environmental conditions. | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/science.1178123 | - |
dc.citation.journaltitle | Science | - |
dc.identifier.wosid | 000269887900043 | - |
dc.identifier.scopusid | 2-s2.0-70349321700 | - |
dc.citation.endpage | 1555 | - |
dc.citation.number | 5947 | - |
dc.citation.startpage | 1552 | - |
dc.citation.volume | 325 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | BACILLUS-SUBTILIS | - |
dc.subject.keywordPlus | PEPTIDOGLYCAN | - |
dc.subject.keywordPlus | GROWTH | - |
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