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비소세포폐암 세포주에서 Uteroglobin Transduction이 COX-2 및 IDO의 발현에 미치는 영향 : Expression of COX-2 and IDO by uteroglobin transduction in NSCLC cell lines
DC Field | Value | Language |
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dc.contributor.author | Park, G.M. | - |
dc.contributor.author | Lee, S.-M. | - |
dc.contributor.author | Yim, J.-J. | - |
dc.contributor.author | Yang, S.-C. | - |
dc.contributor.author | Yoo, C.G. | - |
dc.contributor.author | Lee, C.-T. | - |
dc.contributor.author | Han, S.K. | - |
dc.contributor.author | Shim, Y.-S. | - |
dc.contributor.author | Kim, Y.W. | - |
dc.date.accessioned | 2024-08-08T01:48:07Z | - |
dc.date.available | 2024-08-08T01:48:07Z | - |
dc.date.created | 2023-07-26 | - |
dc.date.created | 2023-07-26 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | Tuberculosis and Respiratory Diseases, Vol.66 No.4, pp.274-279 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208258 | - |
dc.description.abstract | Background: Uteroglobin (UG) is a secretary protein that has strong immunomodulatory properties, and which is synthesized in most epithelia including lung tissue. Overexpression of UG is associated with decreased expression of cyclooxygenase (COX)-2 and suppression of cancer cell growth. Indoleamine 2,3-dioxygenase (IDO) catalyzes tryptophan along the kynurenine pathway, and both the reduction in local tryptophan and the production of tryptophan metabolites contribute to the immunosuppressive effects of IDO. Methods: In this study, we investigated the pattern of expression of COX-2 and IDO, and the effect of UG transduction in the expression of COX-2 and IDO in several non-small cell lung cancer cell lines, especially A549. Results: Both COX-2 and IDO were constitutionally expressed in A549 and H460 cells, and was reduced by UG transduction. In A549 cells, the slightly increased expression of COX-2 and IDO with the instillation of interferon-gamma (IFN- γ) was reduced by UG transduction. However, the reduced expression of COX-2 and IDO by UG transduction was not increased with IFN- γ instillation in A549 cells. In both the A549 COX-2 sense and the A549 COX-2 anti-sense small interfering RNA (siRNA)-transfected cells, IDO was expressed; expression was reduced by UG transduction, irrespective of the expression of COX-2. Conclusion: The results suggest that the anti-proliferative function of UG may be associated with the immune tolerance pathway of IDO, which is independent of the COX-2 pathway. © 2009. | - |
dc.language | 한국어 | - |
dc.publisher | 대한결핵및호흡기학회 | - |
dc.title | 비소세포폐암 세포주에서 Uteroglobin Transduction이 COX-2 및 IDO의 발현에 미치는 영향 | - |
dc.title.alternative | Expression of COX-2 and IDO by uteroglobin transduction in NSCLC cell lines | - |
dc.type | Article | - |
dc.identifier.doi | 10.4046/trd.2009.66.4.274 | - |
dc.citation.journaltitle | Tuberculosis and Respiratory Diseases | - |
dc.identifier.scopusid | 2-s2.0-67649312215 | - |
dc.citation.endpage | 279 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 274 | - |
dc.citation.volume | 66 | - |
dc.identifier.kciid | ART001341040 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, S.-M. | - |
dc.contributor.affiliatedAuthor | Yim, J.-J. | - |
dc.contributor.affiliatedAuthor | Yoo, C.G. | - |
dc.contributor.affiliatedAuthor | Lee, C.-T. | - |
dc.contributor.affiliatedAuthor | Han, S.K. | - |
dc.contributor.affiliatedAuthor | Shim, Y.-S. | - |
dc.contributor.affiliatedAuthor | Kim, Y.W. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | 3-dioxygenase | - |
dc.subject.keywordAuthor | Cyclooxygenase 2 | - |
dc.subject.keywordAuthor | Immune tolerance | - |
dc.subject.keywordAuthor | Indoleamine 2 | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
dc.subject.keywordAuthor | Uteroglobin | - |
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