Publications
Detailed Information
Lack of an association between interleukin-12 receptor beta 1 polymorphisms and tuberculosis in Koreans
Cited 27 time in
Web of Science
Cited 31 time in Scopus
- Authors
- Issue Date
- 2005-07
- Publisher
- Karger AG
- Citation
- Respiration; international review of thoracic diseases, Vol.72 No.4, pp.365-368
- Abstract
- Background: The fact that only 10% of people infected with Mycobacterium tuberculosis develop clinical tuberculosis ( TB) suggests the presence of genetic factors in the pathogenesis of TB. To date, a number of single nucleotide polymorphisms ( SNPs) in several candidate genes have been proposed as genetic risk factors of TB; however, reports are conflicting. Objectives: We investigated whether SNPs in the interleukin (IL)-12 receptor beta 1 gene are associated with TB in Koreans. Methods: One hundred and fifteen patients with bacteriologically or pathologically confirmed TB and 151 healthy anonymous blood donors were enrolled. The genotypes of 5 SNPs on IL-12 receptor beta 1 gene, +705A/G (Q214R), +1158T/C (M365T), +1196G/C (G378R), +1637G/A (A525T) and +1664C/T (P534S), were determined by PCR-RFLP. Results: No difference was observed between TB patients and controls in terms of the genotype frequencies of the 5 SNPs of the IL-12 receptor beta 1 gene or of their haplotypes. Conclusions: In view of the finding that these SNPs have been reported to be associated with TB in the Japanese and Moroccan populations, our results may reflect racial differences in genetic susceptibility to TB. Copyright (C) 2005 S. Karger AG, Basel.
- ISSN
- 0025-7931
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.