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Ras/MAP Kinase pathways are involved in Ras specific apoptosis induced by sodium butyrate
DC Field | Value | Language |
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dc.contributor.author | Jung, Ji Won | - |
dc.contributor.author | Cho, Sung Dae | - |
dc.contributor.author | Ahn, Nam Shik | - |
dc.contributor.author | Yang, Se Ran | - |
dc.contributor.author | Park, Joon Suk | - |
dc.contributor.author | Jo, Eun Hye | - |
dc.contributor.author | Hwang, Jae Woong | - |
dc.contributor.author | Jung, Ji Youn | - |
dc.contributor.author | Kim, Sung Hoon | - |
dc.contributor.author | Kang, Kyung Sun | - |
dc.contributor.author | Lee, Yong Soon | - |
dc.date.accessioned | 2024-08-08T01:50:33Z | - |
dc.date.available | 2024-08-08T01:50:33Z | - |
dc.date.created | 2022-05-20 | - |
dc.date.created | 2022-05-20 | - |
dc.date.issued | 2005-07 | - |
dc.identifier.citation | Cancer Letters, Vol.225 No.2, pp.199-206 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208579 | - |
dc.description.abstract | Histone deacetylase inhibitors such as TSA, SAHA, and NaBu etc. are prospective cancer therapeutics of growing interest. Here, we demonstrated that oncogenic ras-transformed rat liver epithelial (WB-ras) cells were specifically undergone apoptosis by 48 h treatment of NaBu. During this, inhibition of ras proteins, especially farnesylated form of ras, and down-regulation of ERK1/2 were observed, which suggest ras/raf/MEK/ERK down-regulation, while p38 MAP kinase was maintained upregulated. In addition, up-regulation of pro-apoptotic proteins such as p53 and p21(CIPI/WAFI), and down-regulation of cell cycle regulator/anti-apoptotic proteins such as cdk2, -4 and phosphorylated Akt were observed concurrently with an increase in apoptotic cell portion. A phosphatase inhibitor, sodium orthovanadate (SOV), efficiently blocked apoptosis and restored responsible proteins for each phenomenon including ERK1/2 while SB203580, a specific p38 MAP kinase inhibitor, showed minor effect on them. Thus, ras/ERK signaling pathway can be considered in chemotherapeutic strategies of NaBu regardless of its inhibitory action on histone deacetylase. (c) 2004 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Ras/MAP Kinase pathways are involved in Ras specific apoptosis induced by sodium butyrate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.canlet.2004.11.029 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000230381400003 | - |
dc.identifier.scopusid | 2-s2.0-20644467459 | - |
dc.citation.endpage | 206 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 199 | - |
dc.citation.volume | 225 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Sung Dae | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Sun | - |
dc.contributor.affiliatedAuthor | Lee, Yong Soon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | JUNCTIONAL INTERCELLULAR COMMUNICATION | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE | - |
dc.subject.keywordPlus | RAS/RAF/MEK/ERK PATHWAY | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordAuthor | sodium butyrate | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | ras | - |
dc.subject.keywordAuthor | MAP kinase | - |
dc.subject.keywordAuthor | ERK | - |
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