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Toll-like Receptor 2 유전자의 Microsatellite 유전자 다형성과 만성폐쇄성폐질환 발생과의 연관성 결여 : Lack of the association between microsatellite polymorphism in toll-like receptor 2 gene and development of COPD
DC Field | Value | Language |
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dc.contributor.author | Lee, H.S. | - |
dc.contributor.author | Lee, H.W. | - |
dc.contributor.author | Kim, D.K. | - |
dc.contributor.author | Ko, D.S. | - |
dc.contributor.author | Park, G.M. | - |
dc.contributor.author | Hwang, Y.I. | - |
dc.contributor.author | Lee, S.-M. | - |
dc.contributor.author | Yoo, C.G. | - |
dc.contributor.author | Kim, Y.W. | - |
dc.contributor.author | Han, S.K. | - |
dc.contributor.author | Shim, Y.-S. | - |
dc.contributor.author | Yim, J.-J. | - |
dc.date.accessioned | 2024-08-08T01:50:36Z | - |
dc.date.available | 2024-08-08T01:50:36Z | - |
dc.date.created | 2023-07-26 | - |
dc.date.created | 2023-07-26 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | Tuberculosis and Respiratory Diseases, Vol.58 No.4, pp.367-374 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208587 | - |
dc.description.abstract | Background: The fact that only 10-20% of chronic cigarette smokers develop chronic obstructive pulmonary disease (COPD) reflects the presence of genetic factors associated with the susceptibility to COPD. Recently, it was reported that the surfactant protein A increases the secretion of matrix metalloprotease 9, which degrades extracellular matrices of the lung, through a Toll-like receptor 2 (TLR2). In this context, possible role of TLR2 in the pathogenesis of COPD was postulated, and a functional dinucleotide repeat polymorphism in intron II of TLR2 was evaluated for any association with COPD. Method: Male patients with COPD and male smokers with a normal pulmonary function were enrolled in this study. The number of Guanine-Thymine repeats in intron II of the TLR2 gene were counted. Because the distributions of the repeats were trimodal, the alleles were classified into three subclasses, 12-16 repeats: short (S) alleles; 17-22 repeats: medium length (M) alleles; and 23-27 repeats: long (L) alleles. Result: 125 male patients with COPD and 144 age- and gender-matched blood donors with a normal lung function were enrolled. There were no differences in the distribution of each allele subclass (S, M and L) between the COPD and control group (p=0.75). The frequencies of the genotypes with and without each allele subclass in the COPD and control group were similar. Conclusion: A microsatellite polymorphism in intron II of TLR2 gene was not associated with the development of COPD in Koreans. | - |
dc.language | 한국어 | - |
dc.publisher | 대한결핵및호흡기학회 | - |
dc.title | Toll-like Receptor 2 유전자의 Microsatellite 유전자 다형성과 만성폐쇄성폐질환 발생과의 연관성 결여 | - |
dc.title.alternative | Lack of the association between microsatellite polymorphism in toll-like receptor 2 gene and development of COPD | - |
dc.type | Article | - |
dc.identifier.doi | 10.4046/trd.2005.58.4.367 | - |
dc.citation.journaltitle | Tuberculosis and Respiratory Diseases | - |
dc.identifier.scopusid | 2-s2.0-21744461120 | - |
dc.citation.endpage | 374 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 367 | - |
dc.citation.volume | 58 | - |
dc.identifier.kciid | ART000986077 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, S.-M. | - |
dc.contributor.affiliatedAuthor | Yoo, C.G. | - |
dc.contributor.affiliatedAuthor | Kim, Y.W. | - |
dc.contributor.affiliatedAuthor | Han, S.K. | - |
dc.contributor.affiliatedAuthor | Shim, Y.-S. | - |
dc.contributor.affiliatedAuthor | Yim, J.-J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease (COPD) | - |
dc.subject.keywordAuthor | Genetic susceptibility | - |
dc.subject.keywordAuthor | Microsatellite polymorphism | - |
dc.subject.keywordAuthor | Toll-like receptor 2 (TLR2) | - |
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