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비소세포 폐암세포에서 Uteroglobin의 이입에 의한 cPLA2와 COX-2 발현 및 ERK 활성의 변화 : The effect of uteroglobin on cPLA2, COX-2 expression and ERK activation in NSCLC cells
DC Field | Value | Language |
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dc.contributor.author | Kim, W.J. | - |
dc.contributor.author | Yoon, J.M. | - |
dc.contributor.author | Lee, K.H. | - |
dc.contributor.author | Han, S.J. | - |
dc.contributor.author | Shin, W.H. | - |
dc.contributor.author | Yim, J.-J. | - |
dc.contributor.author | Yoo, C.-G. | - |
dc.contributor.author | Lee, C.T. | - |
dc.contributor.author | Han, S.K. | - |
dc.contributor.author | Shim, Y.-S. | - |
dc.contributor.author | Kim, Y.W. | - |
dc.date.accessioned | 2024-08-08T01:50:59Z | - |
dc.date.available | 2024-08-08T01:50:59Z | - |
dc.date.created | 2023-07-26 | - |
dc.date.created | 2023-07-26 | - |
dc.date.issued | 2004-06 | - |
dc.identifier.citation | Tuberculosis and Respiratory Diseases, Vol.56 No.6, pp.638-645 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208639 | - |
dc.description.abstract | Background: Uteroglobin is a protein produced by the normal bronchial epithelium and its expression level is lower in non-small cell lung cancer tissues and cell lines. It mainly functions as an anti-inflammatory, and when it is overexpressed in cancer cells, the neoplastic phenotype is antagonized. cPLA2 and COX-2, which are also associated with inflammation, were reported to be related to cancer. The relationship between cPLA2, COX-2 and uteroglobin is unclear. The relationship between uteroglobin and ERK, which is related to cell growth, is also not unclear. This study investigated the changes in the cPLA2 and COX-2 expression levels and the ERK activities after the overexpression of uteroglobin in non-small cell lung cancer cell lines. Methods: The A549 and NCI-H460 cell lines were infected by adenovirus-null and adenovirus-uteroglobin. The cChange in the cPLA2, COX-2 expression level and ERK activity after uteroglobin overexpression was measured by Western blot. The change in MMP activity was measured by zymography. Results: Western blot revealed decreased expression levels of cPLA2, and COX-2, and increased pERK levels in nonsmall cell lung cancer cells after uteroglobin overexpression. Zymography revealed no changes in the MMP-2 activity and lower MMP-9 activity. U0126, which is a specific inhibitor of ERK-activating kinase MEK-1/-2, prevented the decrease in the MMP-9 activity Conclusions: A decrease in cPLA2 expression, COX-2 expression, MMP-9 activity and a increase in ERK activity may be related to the anticancer effects of uteroglobin in nonsmall cell lung cancer cells. | - |
dc.language | 한국어 | - |
dc.publisher | 대한결핵및호흡기학회 | - |
dc.title | 비소세포 폐암세포에서 Uteroglobin의 이입에 의한 cPLA2와 COX-2 발현 및 ERK 활성의 변화 | - |
dc.title.alternative | The effect of uteroglobin on cPLA2, COX-2 expression and ERK activation in NSCLC cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.4046/trd.2004.56.6.638 | - |
dc.citation.journaltitle | Tuberculosis and Respiratory Diseases | - |
dc.identifier.scopusid | 2-s2.0-4444276797 | - |
dc.citation.endpage | 645 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 638 | - |
dc.citation.volume | 56 | - |
dc.identifier.kciid | ART001117154 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Yim, J.-J. | - |
dc.contributor.affiliatedAuthor | Yoo, C.-G. | - |
dc.contributor.affiliatedAuthor | Lee, C.T. | - |
dc.contributor.affiliatedAuthor | Han, S.K. | - |
dc.contributor.affiliatedAuthor | Shim, Y.-S. | - |
dc.contributor.affiliatedAuthor | Kim, Y.W. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | CPLA2 | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Uteroglobin | - |
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