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Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction : Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction
DC Field | Value | Language |
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dc.contributor.author | Choi, Youn Hee | - |
dc.contributor.author | Kim, Ha Il | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Yu, Dae Yeul | - |
dc.contributor.author | Cho, Hye Seong | - |
dc.contributor.author | Lee, Mi Ock | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Ahn, Yong Ho | - |
dc.contributor.author | Kim, Se Jong | - |
dc.contributor.author | Park, Jeon Han | - |
dc.date.accessioned | 2024-08-08T01:51:05Z | - |
dc.date.available | 2024-08-08T01:51:05Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.citation | FEBS Letters, Vol.557 No.1-3, pp.73-80 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/208658 | - |
dc.description.abstract | Ligand activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARgamma activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARgamma ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARgamma and HBx/PPARgamma interaction blocked nuclear localization and binding to recognition site of PPARgamma. HBx significantly suppressed a PPARgamma-mediated transactivation. These results suggest that HBx modulates PPARgamma function through protein-protein interaction. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All Rights Reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction | - |
dc.title.alternative | Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0014-5793(03)01449-2 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000188648100013 | - |
dc.identifier.scopusid | 2-s2.0-9144250174 | - |
dc.citation.endpage | 80 | - |
dc.citation.number | 1-3 | - |
dc.citation.startpage | 73 | - |
dc.citation.volume | 557 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Mi Ock | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN PROSTATE-CANCER | - |
dc.subject.keywordPlus | HEPATOMA-CELL LINES | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVITY | - |
dc.subject.keywordPlus | RESPONSE ELEMENTS | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | LIVER-CANCER | - |
dc.subject.keywordAuthor | hepatitis B virus X protein | - |
dc.subject.keywordAuthor | peroxisome proliferator-activated receptor gamma | - |
dc.subject.keywordAuthor | transactivation | - |
dc.subject.keywordAuthor | protein-protein interaction | - |
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