Publications

Detailed Information

The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor-positive and estrogen receptor-negative human breast cancers

Cited 39 time in Web of Science Cited 43 time in Scopus
Authors

Chung, Heekyoung; Jung, Ji-Youn; Cho, Sung Dae; Hong, Kyung-A.; Kim, Hyun-Jun; Shin, Dong-Hui; Kim, Hwan; Kim, Hea Ok; Shin, Dae Hong; Lee, Hyuk Woo; Jeong, Lak Shin; Kong, Gu

Issue Date
2006-03
Publisher
American Association for Cancer Research
Citation
Molecular Cancer Therapeutics, Vol.5 No.3, pp.685-692
Abstract
Agonists to A3 adenosine receptor (A3AR) have been reported to inhibit cell growth and/or induce apoptosis in various tumors. We tested the effect of a novel A3AR agonist generically known as LJ-529 in breast cancer cells. Anchorage-dependent cell growth and in vivo tumor growth were attenuated by LJ-529, independently of its estrogen receptor (ER) alpha status. In addition, apoptosis was induced as evidenced by the activation of caspase-3 and c-poly (ADP)ribose polymerase. Furthermore, the Wnt signaling pathway was down-regulated and P27(kip) was induced by LJ-529. In ER-positive cells, the expression of ER was down-regulated by LJ-529, which might have additionally contributed to attenuated cell proliferation. In ER-negative, c-ErbB2-overexpressing SK-BR-3 cells, the expression of c-ErbB2 and its downstream extracellular signal-regulated kinase pathway were down-regulated by LJ-529. However, such effect of LJ-529 acted independently of its receptor because no A3AR was detected by reverse transcription-PCR in all four cell lines tested. In conclusion, our novel findings open the possibility of LJ-529 as an effective therapeutic agent against both ER-positive and ER-negative breast cancers, particularly against the more aggressive ER-negative, c-ErbB2-overexpressing types.
ISSN
1535-7163
URI
https://hdl.handle.net/10371/208988
DOI
https://doi.org/10.1158/1535-7163.MCT-05-0245
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • School of Dentistry
  • Department of Dentistry
Research Area Discovery of molecular targets related to oral cancer metastasis and identification of signal transduction system, Identifying the role of immunological tolerance in oral cancer, Presenting a new concept oral cancer prevention and treatment strategy through identification of major molecular targets and mechanisms related to oral cancer development, 구강암 발병관련 주요 분자표적 및 기전 규명을 통한 신개념 구강암 예방 및 치료전략 제시, 구강암 전이관련 분자표적 발굴 및 신호전달체계 규명, 구강암에서 면연관용의 역할 규명

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share