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The prognostic role of soluble transforming growth factor-beta and its correlation with soluble programmed death-ligand 1 in biliary tract cancer : The prognostic role of soluble transforming growth factor-β and its correlation with soluble programmed death-ligand 1 in biliary tract cancer
Cited 3 time in
Web of Science
Cited 3 time in Scopus
- Authors
- Issue Date
- 2021-02
- Publisher
- Blackwell Publishing Inc.
- Citation
- Liver International, Vol.41 No.2, pp.388-395
- Abstract
- Background This study aimed to evaluate the association between soluble TGF-beta (sTGF-beta) and soluble PD-L1 (sPDL1), the dynamics of sTGF-beta during treatment and its prognostic role in biliary tract cancer (BTC). Methods The study population consisted of 90 BTC patients with first-line chemotherapy (cohort 1) and 35 BTC patients with second- or third-line chemotherapy (cohort 2). Plasma sTGF-beta and sPDL1 levels were measured using an enzyme-linked immunosorbent assay. Results In both groups, sTGF-beta was positive correlated with sPDL1 for baseline and change values after treatment. sTGF-beta was elevated at disease progression compared to baseline in cohort 1 (P < .001). Increased sTGF-beta after treatment revealed worse DFS and OS (P = .024, P = .028, respectively) in cohort 1 and significantly shorter OS (P = .020) in cohort 2. In multivariable analysis, this prognostic value of increased sTGF-beta for OS retained its significance in both cohorts (Hazard ratio (HR) = 1.8, 95% CI, 1.1-3.0, P = .028, in cohort 1; HR = 4.7, 95% CI, 1.5-14.6, P = .007, in cohort 2). Conclusions In BTC, sTGF-beta was positively correlated with sPDL1 for baseline and changes after chemotherapy, and increased as tumour burden. sTGF-beta could be associated with survival; particularly, an elevated value after treatment suggests worse prognosis.
- ISSN
- 1478-3223
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