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The prognostic role of soluble transforming growth factor-beta and its correlation with soluble programmed death-ligand 1 in biliary tract cancer : The prognostic role of soluble transforming growth factor-β and its correlation with soluble programmed death-ligand 1 in biliary tract cancer

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors

Kim, Jin Won; Lee, Kyung-Hun; Kim, Ji-Won; Suh, Koung Jin; Nam, Ah-Rong; Bang, Ju-Hee; Jin, Mei Hua; Oh, Kyoung-Seok; Kim, Jae-Min; Kim, Tae-Yong; Oh, Do-Youn

Issue Date
2021-02
Publisher
Blackwell Publishing Inc.
Citation
Liver International, Vol.41 No.2, pp.388-395
Abstract
Background This study aimed to evaluate the association between soluble TGF-beta (sTGF-beta) and soluble PD-L1 (sPDL1), the dynamics of sTGF-beta during treatment and its prognostic role in biliary tract cancer (BTC). Methods The study population consisted of 90 BTC patients with first-line chemotherapy (cohort 1) and 35 BTC patients with second- or third-line chemotherapy (cohort 2). Plasma sTGF-beta and sPDL1 levels were measured using an enzyme-linked immunosorbent assay. Results In both groups, sTGF-beta was positive correlated with sPDL1 for baseline and change values after treatment. sTGF-beta was elevated at disease progression compared to baseline in cohort 1 (P < .001). Increased sTGF-beta after treatment revealed worse DFS and OS (P = .024, P = .028, respectively) in cohort 1 and significantly shorter OS (P = .020) in cohort 2. In multivariable analysis, this prognostic value of increased sTGF-beta for OS retained its significance in both cohorts (Hazard ratio (HR) = 1.8, 95% CI, 1.1-3.0, P = .028, in cohort 1; HR = 4.7, 95% CI, 1.5-14.6, P = .007, in cohort 2). Conclusions In BTC, sTGF-beta was positively correlated with sPDL1 for baseline and changes after chemotherapy, and increased as tumour burden. sTGF-beta could be associated with survival; particularly, an elevated value after treatment suggests worse prognosis.
ISSN
1478-3223
URI
https://hdl.handle.net/10371/212766
DOI
https://doi.org/10.1111/liv.14636
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  • College of Medicine
  • Department of Medicine
Research Area DNA 손상 반응 타겟 물질의 면역조절 효과, Effect of DNA damage response target substances on immunomodulatory action, Efficacy and biomarker validation studies of targeted therapeutics, Resistance mechanisms according to targeted therapeutics, 표적 항암제 내성 기전 연구, 표적 항암제의 효과 검증 및 바이오마커 규명

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