The impact of selcopintide on periodontal regeneration in a class II furcation defect model: a radiographic and histomorphometric analysis

Abstract

Objectives This study investigated the effect of Selcopintide (SCPT) on periodontal regeneration using surgically created class II furcation defects in an animal model, employing both radiographical and histological evaluations. Materials and methods Class II furcation defects were surgically induced in six beagle dogs. Each defect was unilaterally and randomly assigned to one of five treatment groups: (1) no treatment (control), (2) guided tissue regeneration (GTR) with a collagenated bone substitute and a collagen membrane, (3) GTR with an enamel matrix derivative (GTR/EMD), (4) GTR with 2 mg/ml SCPT (GTR/SCPT2), or (5) GTR with 4 mg/ml SCPT (GTR/SCPT4). Six weeks after initial surgery, identical procedures were performed on the contralateral area. Healing outcomes were assessed at 6 and 12 weeks through radiographic and histomorphometric analyses. The primary outcome was the length of the root surface covered by new cementum assessed histologically and the secondary outcome included other histomorphometric and radiographic healing outcomes. Results Radiographically, the GTR/SCPT groups showed significantly greater new bone volume than the control group at both 6- and 12-week timepoints (p < 0.05). Histologically, specimens treated with both formulations of SCPT displayed better-organized periodontal ligaments and improved cementum formation, similar to those treated with EMD. The group with the highest concentration of SCPT (GTR/SCPT4) exhibited the greatest amount of new cementum formation. Conclusions Within the limitations of this study, both formulations of SCPT demonstrated significant regenerative potential in periodontal tissues, with outcomes comparable to those of EMD treatment, suggesting SCPT's viability as an alternative bioactive agent for periodontal regeneration in class II furcation defects.