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Immunohistochemical study on the distribution of sodium-dependent vitamin C transporters in the respiratory system of adult rat

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dc.contributor.authorJin, Shun Nu-
dc.contributor.authorMun, Ga Hee-
dc.contributor.authorLee, Ju Hyun-
dc.contributor.authorOh, Chang Seok-
dc.contributor.authorKim, Jaehyup-
dc.contributor.authorChung, Yoon Hee-
dc.contributor.authorKang, Jae Seung-
dc.contributor.authorKim, Joong-Gon-
dc.contributor.authorHwang, Douk-Ho-
dc.contributor.authorHwang, Young Il-
dc.contributor.authorShin, Dong Hoon-
dc.contributor.authorLee, Wang Jae-
dc.date.accessioned2009-12-23T06:05:59Z-
dc.date.available2009-12-23T06:05:59Z-
dc.date.issued2005-12-17-
dc.identifier.citationMicrosc Res Tech. 2005 Dec 15;68(6):360-7.en
dc.identifier.issn1059-910X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16358281-
dc.identifier.urihttp://hdl.handle.net/10371/22155-
dc.description.abstractAs vitamin C (L-ascorbic acid, VC) is known to be essential for many enzymatic reactions, the study on the transport mechanism of VC through cytoplasmic membrane is crucial to understanding physiological role of VC in cells and the respiratory system. In this regard, the study on the newly identified sodium-dependent VC transporters (SVCTs), SVCT1 and SVCT2, is required in organs that contain high concentration of VC. We have shown the distribution of SVCT proteins in the respiratory system, which has been reported to be one of the organs with a high concentration of VC, using immunohistochemical techniques. In the present study, intense SVCT immunoreactivities (IRs) were mainly localized in the respiratory system epithelial cells. In the trachea, both SVCT1 and 2 were localized in the psuedostratified ciliated columnar epithelium. In the terminal bronchiole, SVCT1 and 2 IRs were mainly observed in the apical portion of the simple columnar epithelium. In addition, SVCT IRs was localized within the cell membrane of some alveolar cells, even though we could not identify the exact cell types. These results provide the first evidence that intense SVCT1 and 2 IRs were found in the apical portion of the respiratory epithelial cells, suggesting that SVCT proteins in the apical portion could transport the reduced form of VC included in the airway surface liquid into the respiratory epithelial cells.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectAscorbic Acid/*metabolismen
dc.subjectBiological Transporten
dc.subjectImmunohistochemistry/methodsen
dc.subjectOrganic Anion Transporters, Sodium-Dependent/*metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectRespiratory System/*metabolismen
dc.subjectSodium/*metabolismen
dc.subjectSymporters/*metabolismen
dc.subjectTrachea/cytologyen
dc.titleImmunohistochemical study on the distribution of sodium-dependent vitamin C transporters in the respiratory system of adult raten
dc.typeArticleen
dc.contributor.AlternativeAuthor진순녀-
dc.contributor.AlternativeAuthor문가희-
dc.contributor.AlternativeAuthor이주현-
dc.contributor.AlternativeAuthor오창석-
dc.contributor.AlternativeAuthor김재협-
dc.contributor.AlternativeAuthor정윤희-
dc.contributor.AlternativeAuthor강재승-
dc.contributor.AlternativeAuthor김중곤-
dc.contributor.AlternativeAuthor황덕호-
dc.contributor.AlternativeAuthor황영일-
dc.contributor.AlternativeAuthor신동훈-
dc.contributor.AlternativeAuthor이왕재-
dc.identifier.doi10.1002/jemt.20255-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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