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Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions

Cited 53 time in Web of Science Cited 58 time in Scopus
Authors
Song, J.; Lee, S. T.; Kang, W.; Park, J. E.; Chu, K.; Lee, S. E.; Hwang, T.; Chung, H.; Kim, M.
Issue Date
2007-08-03
Publisher
Elsevier
Citation
Neurosci Lett. 2007 Aug 9;423(1):58-61. Epub 2007 Jul 14.
Keywords
AnimalsApomorphine/*pharmacologyCell DifferentiationCell LineDopamine Agonists/*pharmacologyEmbryonic Stem Cells/*transplantationHuntington Disease/chemically induced/*therapyImmunohistochemistryMaleMicroinjectionsNeostriatumNeurons/*transplantationNeurotoxicity Syndromes/*psychology/*therapyQuinolinic Acid/administration & dosage/*toxicityRatsRats, Sprague-DawleyStereotyped Behavior/*drug effectsStromal Cells/physiology/transplantation
Abstract
To test the efficacy of human embryonic stem cell (hESC)-derived neural precursors in an experimental model of Huntington's disease (HD), we differentiated hESC into nestin-positive neural precursors by co-culturing with PA6 stromal cells, and subsequently transplanted them into the striatum of quinolinic acid (QA)-induced HD model. The transplanted animals exhibited a behavioral recovery in the apomorphine-induced rotation test for 3 weeks after transplantation. The transplanted hESC-derived neural precursors were found in both cortex and striatum. They also exhibited some evidence of neuronal differentiation. At the time of examination, no tumor was detected. These results strongly suggest that hESC-derived neural precursors can lead to a behavioral recovery, as well as neuronal differentiation, in the pre-clinical model of HD.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4P6M66C-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=30abca33a5be8a1af55234b8179b1550

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17669593

https://hdl.handle.net/10371/22227
DOI
https://doi.org/10.1016/j.neulet.2007.05.066
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College of Medicine/School of Medicine (의과대학/대학원)Neuroscience (뇌신경과학전공)Journal Papers (저널논문_뇌신경과학전공)
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