S-Space College of Medicine/School of Medicine (의과대학/대학원) Neuroscience (뇌신경과학전공) Journal Papers (저널논문_뇌신경과학전공)
Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions
- Song, J.; Lee, S. T.; Kang, W.; Park, J. E.; Chu, K.; Lee, S. E.; Hwang, T.; Chung, H.; Kim, M.
- Issue Date
- Neurosci Lett. 2007 Aug 9;423(1):58-61. Epub 2007 Jul 14.
- Animals; Apomorphine/*pharmacology; Cell Differentiation; Cell Line; Dopamine Agonists/*pharmacology; Embryonic Stem Cells/*transplantation; Huntington Disease/chemically induced/*therapy; Immunohistochemistry; Male; Microinjections; Neostriatum; Neurons/*transplantation; Neurotoxicity Syndromes/*psychology/*therapy; Quinolinic Acid/administration & dosage/*toxicity; Rats; Rats, Sprague-Dawley; Stereotyped Behavior/*drug effects; Stromal Cells/physiology/transplantation
- To test the efficacy of human embryonic stem cell (hESC)-derived neural precursors in an experimental model of Huntington's disease (HD), we differentiated hESC into nestin-positive neural precursors by co-culturing with PA6 stromal cells, and subsequently transplanted them into the striatum of quinolinic acid (QA)-induced HD model. The transplanted animals exhibited a behavioral recovery in the apomorphine-induced rotation test for 3 weeks after transplantation. The transplanted hESC-derived neural precursors were found in both cortex and striatum. They also exhibited some evidence of neuronal differentiation. At the time of examination, no tumor was detected. These results strongly suggest that hESC-derived neural precursors can lead to a behavioral recovery, as well as neuronal differentiation, in the pre-clinical model of HD.
- 0304-3940 (Print)
- Files in This Item: There are no files associated with this item.