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Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions
Cited 58 time in
Web of Science
Cited 66 time in Scopus
- Authors
- Issue Date
- 2007-08-03
- Publisher
- Elsevier
- Citation
- Neurosci Lett. 2007 Aug 9;423(1):58-61. Epub 2007 Jul 14.
- Keywords
- Animals ; Apomorphine/*pharmacology ; Cell Differentiation ; Cell Line ; Dopamine Agonists/*pharmacology ; Embryonic Stem Cells/*transplantation ; Huntington Disease/chemically induced/*therapy ; Immunohistochemistry ; Male ; Microinjections ; Neostriatum ; Neurons/*transplantation ; Neurotoxicity Syndromes/*psychology/*therapy ; Quinolinic Acid/administration & dosage/*toxicity ; Rats ; Rats, Sprague-Dawley ; Stereotyped Behavior/*drug effects ; Stromal Cells/physiology/transplantation
- Abstract
- To test the efficacy of human embryonic stem cell (hESC)-derived neural precursors in an experimental model of Huntington's disease (HD), we differentiated hESC into nestin-positive neural precursors by co-culturing with PA6 stromal cells, and subsequently transplanted them into the striatum of quinolinic acid (QA)-induced HD model. The transplanted animals exhibited a behavioral recovery in the apomorphine-induced rotation test for 3 weeks after transplantation. The transplanted hESC-derived neural precursors were found in both cortex and striatum. They also exhibited some evidence of neuronal differentiation. At the time of examination, no tumor was detected. These results strongly suggest that hESC-derived neural precursors can lead to a behavioral recovery, as well as neuronal differentiation, in the pre-clinical model of HD.
- ISSN
- 0304-3940 (Print)
- Language
- English
- URI
- http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4P6M66C-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=30abca33a5be8a1af55234b8179b1550
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17669593
https://hdl.handle.net/10371/22227
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