Publications
Detailed Information
Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, S. T. | - |
dc.contributor.author | Park, J. E. | - |
dc.contributor.author | Kim, D. H. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Im, W. S. | - |
dc.contributor.author | Kang, L. | - |
dc.contributor.author | Jung, S. H. | - |
dc.contributor.author | Kim, M. W. | - |
dc.contributor.author | Chu, K. | - |
dc.contributor.author | Kim, M. | - |
dc.date.accessioned | 2009-12-24T07:35:11Z | - |
dc.date.available | 2009-12-24T07:35:11Z | - |
dc.date.issued | 2008-01-02 | - |
dc.identifier.citation | Brain Res. 2008 Feb 15;1194:130-7. Epub 2007 Dec 7. | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4R98K8V-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a4237208943899212b2792b39b036aa5 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18166168 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22332 | - |
dc.description.abstract | Huntington's disease (HD) has a mitochondrial dysfunction causing the vulnerability to the excitotoxicity and activations of multiple cell death pathways. Recent evidences suggest that the hematopoietic cytokine, granulocyte-colony stimulating factor (G-CSF), exerts pleiotropic neuroprotection in acute neural injury with activating various survival pathways. Thus, we investigated whether G-CSF can modulate neurodegeneration in an HD animal model induced by 3-nitropropionic acid (3NP), which inhibits mitochondrial succinate dehydrogenase complex II. Either G-CSF (50 microg/kg/day) or saline (as vehicle) was administered intraperitoneally for 5 days with 3NP (63 mg/kg/day) continuous osmotic pump infusion into male Lewis rats. We measured motor scales (0-8) daily and sacrificed rats at 5 days. We observed that G-CSF receptors were expressed in 3NP-induced degenerating striatum. Rats treated with G-CSF showed less degree of neurologic deficits. In the G-CSF-treated rats, the striatal lesion volume measured by Nissl staining, TUNEL+ apoptotic cells, Fluorojade C+ degenerating neurons, and c-Jun+ cells were all decreased. In western blotting, G-CSF activated survival pathways including p-ERK, p-eNOS, p-STAT3, and p-Akt. In summary, G-CSF was found to have neuroprotective effects and save striatal cells through activations of survival pathways in the 3NP-induced striatal degeneration model for HD. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Corpus Striatum/drug effects/*pathology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Drug Interactions | en |
dc.subject | Gene Expression Regulation/drug effects/physiology | en |
dc.subject | Granulocyte Colony-Stimulating Factor/*therapeutic use | en |
dc.subject | Huntington Disease/*chemically induced/*complications | en |
dc.subject | In Situ Nick-End Labeling | en |
dc.subject | Male | en |
dc.subject | Organic Chemicals/diagnostic use | en |
dc.subject | Rats | en |
dc.subject | Rats, Inbred Lew | en |
dc.subject | Signal Transduction/*drug effects/physiology | en |
dc.subject | Statistics, Nonparametric | en |
dc.subject | Neurodegenerative Diseases/drug therapy/etiology/pathology | - |
dc.subject | Nitro Compounds | - |
dc.subject | Propionic Acids | - |
dc.title | Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 김승찬 | - |
dc.contributor.AlternativeAuthor | 임우석 | - |
dc.contributor.AlternativeAuthor | 강라미 | - |
dc.contributor.AlternativeAuthor | 정세희 | - |
dc.contributor.AlternativeAuthor | 김민욱 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.identifier.doi | 10.1016/j.brainres.2007.11.058 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.