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Stem cell-based cell therapy for Huntington disease: a review

Cited 35 time in Web of Science Cited 42 time in Scopus
Authors
Kim, M.; Lee, S. T.; Chu, K.; Kim, S. U.
Issue Date
2007-12-12
Publisher
Wiley-Blackwell
Citation
Neuropathology. 2008 Feb;28(1):1-9. Epub 2007 Dec 5.
Keywords
AnimalsHumansHuntington Disease/*therapyNeurons/*cytologyStem Cell Transplantation/*methods
Abstract
Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell-based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.
ISSN
0919-6544 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18069970

http://hdl.handle.net/10371/22342
DOI
https://doi.org/10.1111/j.1440-1789.2007.00858.x
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College of Medicine/School of Medicine (의과대학/대학원)Neuroscience (뇌신경과학전공)Journal Papers (저널논문_뇌신경과학전공)
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