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Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Yoo, Y.; Choung, J. T.; Yu, J.; Kim do, K.; Choi, S. H.; Koh, Y. Y.
Issue Date
2007-05-17
Publisher
American College of Chest Physicians (ACCP)
Citation
Chest. 2007 Jul;132(1):106-11. Epub 2007 May 15.
Keywords
AdolescentAsthma/blood/pathology/*physiopathologyBronchial Hyperreactivity/blood/pathology/*physiopathologyBronchial Provocation Tests/*methodsBronchoconstrictor Agents/administration & dosageChildDose-Response Relationship, DrugEosinophils/pathologyFemaleForced Expiratory Volume/*physiologyHumansImmunoglobulin E/bloodMaleMethacholine Chloride/administration & dosageRetrospective StudiesSeverity of Illness IndexVital Capacity/*physiology
Abstract
BACKGROUND: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV(1) (PC(20)). The percentage fall in FVC at the PC(20) (DeltaFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC(20). The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to DeltaFVC. METHODS: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC(20) < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC(20) were selected (mild asthma group). The DeltaFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. RESULTS: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (+/- SD) DeltaFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 +/- 3.6%) than in the mild asthma group (16.9 +/- 4.3%). CONCLUSIONS: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.
ISSN
0012-3692 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17505037

https://hdl.handle.net/10371/22356
DOI
https://doi.org/10.1378/chest.06-2943
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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