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Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis
DC Field | Value | Language |
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dc.contributor.author | Lee, E. B. | - |
dc.contributor.author | Zhao, J. | - |
dc.contributor.author | Kim, J. Y. | - |
dc.contributor.author | Xiong, M. | - |
dc.contributor.author | Song, Y. W. | - |
dc.date.accessioned | 2009-12-24T08:14:38Z | - |
dc.date.available | 2009-12-24T08:14:38Z | - |
dc.date.issued | 2007-06-30 | - |
dc.identifier.citation | Arthritis Rheum. 2007 Jul;56(7):2443-8. | en |
dc.identifier.issn | 0004-3591 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17599774 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22394 | - |
dc.description.abstract | OBJECTIVE: To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc). METHODS: To identify the risk of SSc conferred by genetic polymorphisms in the chemokine pathway, 10 single-nucleotide polymorphisms (SNPs) from 8 candidate genes were studied in 99 patients with SSc and 198 age- and sex-matched controls in a Korean population. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism or sequence-specific primer methods. Genetic associations between each SNP and SSc risk, calculated as odds ratios with 95% confidence intervals, were estimated using chi-square tests. Haplotypes for the 2 polymorphisms in the gene CCL5 (RANTES) were constructed, and their associations with SSc were tested. Gene-gene interactions were investigated using a recently described novel method, and the results were confirmed by conditional logistic regression. Adjustment for multiple testing was based on Bonferroni correction. RESULTS: There was significant evidence of gene-gene interaction between polymorphisms in the genes CXCL8 (interleukin-8) and CCL5, and both of these were associated with an increased risk of SSc. This SNP-SNP interaction was confirmed by 2 independent statistical methods. The associations remained significant after Bonferroni adjustment for multiple testing. No significant association between each individual SNP or haplotype and the risk of SSc was found. CONCLUSION: Crosstalk between the 2 chemokines CXCL8 and CCL5 may contribute to the susceptibility to SSc. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Chemokine CCL5 | en |
dc.subject | Chemokines/*genetics | en |
dc.subject | Chemokines, CC/genetics | en |
dc.subject | Humans | en |
dc.subject | Interleukin-8/genetics | en |
dc.subject | Korea | en |
dc.subject | Reference Values | en |
dc.subject | Scleroderma, Systemic/*genetics | en |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.contributor.AlternativeAuthor | 김정연 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.identifier.doi | 10.1002/art.22742 | - |
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