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Clinical characteristics of tuberculosis in patients with liver cirrhosis

Cited 44 time in Web of Science Cited 40 time in Scopus
Authors
Cho, Y. J.; Lee, S. M.; Yoo, C. G.; Kim, Y. W.; Han, S. K.; Shim, Y. S.; Yim, J. J.
Issue Date
2007-06-02
Publisher
Wiley-Blackwell
Citation
Respirology. 2007 May;12(3):401-5.
Keywords
AdultAgedAntibiotics, Antitubercular/adverse effects/therapeutic useCase-Control StudiesDrug Therapy, CombinationFemaleHumansIsoniazid/adverse effects/therapeutic useLiver/drug effectsLiver Cirrhosis/*complicationsMaleMiddle AgedPrognosisRifampin/adverse effects/therapeutic useTuberculosis, Pulmonary/diagnosis/*drug therapy/*etiology
Abstract
BACKGROUND AND OBJECTIVES: Patients with liver cirrhosis are likely to be susceptible to tuberculosis (TB) because of immune system dysfunction. The aim of this study was to elucidate the clinical characteristics and treatment responses in TB patients with cirrhosis. METHODS: Cases were patients with TB detected during their follow up for liver cirrhosis over a 4-year period. Controls were randomly selected patients with TB but no liver disease, matched to cases by age and gender in a 3:1 ratio. RESULTS: Thirty-six cases and 108 controls were enrolled. Extrapulmonary TB was more common in cases than controls (31% vs 12%, P = 0.02). Clinical and radiographic manifestations and response to treatment did not differ between the two groups. The frequency of hepatotoxicity was higher in the cases than in the controls who were treated with a regimen containing rifampicin and isoniazid, although the difference was not statistically significant (27% vs 10%, P = 0.079). CONCLUSIONS: TB patients with liver cirrhosis show extrapulmonary involvement more frequently. Patients with pulmonary TB and cirrhosis usually respond well to anti-TB treatment although appear to present more frequently with treatment-related hepatotoxicity.
ISSN
1323-7799 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17539845

https://hdl.handle.net/10371/22547
DOI
https://doi.org/10.1111/j.1440-1843.2007.01069.x
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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