Publications
Detailed Information
Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, K. C. | - |
dc.contributor.author | Cho, S. Y. | - |
dc.contributor.author | Lee, H. S. | - |
dc.contributor.author | Jeon, Y. K. | - |
dc.contributor.author | Chung, J. H. | - |
dc.contributor.author | Jung, K. C. | - |
dc.contributor.author | Chung, D. H. | - |
dc.date.accessioned | 2009-12-24T10:11:25Z | - |
dc.date.available | 2009-12-24T10:11:25Z | - |
dc.date.issued | 2006-09-05 | - |
dc.identifier.citation | Arch Pathol Lab Med. 2006 Sep;130(9):1320-5. | en |
dc.identifier.issn | 1543-2165 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16948518 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22562 | - |
dc.description.abstract | CONTEXT: E-Cadherin and beta-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and beta-catenin expressions of this tumor have not been documented, to our knowledge. OBJECTIVE: To characterize the E-cadherin and beta-catenin expressions in SRCC of the lung. DESIGN: An immunohistochemical evaluation of E-cadherin and beta-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. RESULTS: Membranous E-cadherin and beta-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear beta-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear beta-catenin accumulation (0/10). CONCLUSIONS: Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or beta-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and beta-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs. | en |
dc.language.iso | en | - |
dc.publisher | College of American Pathologists | en |
dc.subject | Adenocarcinoma/*pathology | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Cadherins/*metabolism | en |
dc.subject | Carcinoma, Signet Ring Cell/*pathology | en |
dc.subject | Colorectal Neoplasms/*pathology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Lung Neoplasms/*pathology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Retrospective Studies | en |
dc.subject | Stomach Neoplasms/*pathology | en |
dc.subject | Tumor Markers, Biological/analysis | en |
dc.subject | beta Catenin/*metabolism | en |
dc.title | Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문경철 | - |
dc.contributor.AlternativeAuthor | 조수연 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.