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Increased levels of BAL cysteinyl leukotrienesinacute [corrected] RSV bronchiolitis

Cited 19 time in Web of Science Cited 21 time in Scopus
Authors
Kim, C. K.; Koh, J. Y.; Han, T. H.; Kim do, K.; Kim, B. I.; Koh, Y. Y.
Issue Date
2006-05-25
Publisher
Blackwell Publishing
Citation
Acta Paediatr. 2006 Apr;95(4):479-85.
Keywords
Acute DiseaseAsthma/*metabolism/pathologyBronchiolitis, Viral/*metabolism/pathology/virologyBronchoalveolar Lavage Fluid/*chemistry/cytology/virologyCase-Control StudiesChild, PreschoolEosinophilsFemaleHumansInfantLeukocyte CountMaleRespiratory Syncytial Virus Infections/*metabolism/pathologySRS-A/*analysis
Abstract
BACKGROUND: Cysteinyl leukotrienes (CysLTs), including LTC4, LTD4 and LTE4, are pivotal mediators in the pathophysiology of asthma. AIM: To determine whether CysLT levels are increased in the lower airways of children with respiratory syncytial virus (RSV) bronchiolitis, as they are in asthmatic children, and to investigate a possible heterogeneity in CysLT levels in children with RSV bronchiolitis. METHODS: Bronchoalveolar lavage (BAL) fluids were obtained from children with acute RSV bronchiolitis (n = 20), from children with acute asthma who had no identifiable virus infection (n = 16) and from control subjects (n = 14). BAL cell counts and differentials were determined, and the concentrations of CysLTs were measured by ELISA. RESULTS: CysLT levels in the asthma (70.6 +/- 52.7 pg/ml, p < 0.001) and bronchiolitis groups (21.9 +/- 23.3 pg/ml, p < 0.05) were significantly higher than in the control group (8.7 +/- 5.2 pg/ml). Among bronchiolitis subjects, the eosinophil-positive subgroup (n = 6) showed significantly higher CysLT levels (49.0 +/- 26.7 pg/ml, p = 0.001) than the control group, but this was not observed in the eosinophil-negative subgroup (n = 14, 10.3 +/- 6.3 pg/ml, p = 0.47). CONCLUSION: CysLT levels are increased in the lower airways during RSV bronchiolitis, although their intensities are lower than those in acute asthma. Among bronchiolitis subjects, high CysLT producers could be distinguished from low CysLT producers by the presence of eosinophilia in BAL fluids, suggesting a pathophysiological heterogeneity in RSV bronchiolitis.
ISSN
0803-5253 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16720498

https://hdl.handle.net/10371/22584
DOI
https://doi.org/10.1080/08035250600554268
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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