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IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, S. J. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Park, W. S. | - |
dc.contributor.author | Chung, D. H. | - |
dc.date.accessioned | 2009-12-24T10:56:14Z | - |
dc.date.available | 2009-12-24T10:56:14Z | - |
dc.date.issued | 2006-10-04 | - |
dc.identifier.citation | J Immunol. 2006 Oct 15;177(8):5258-68. | en |
dc.identifier.issn | 0022-1767 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17015711 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22591 | - |
dc.description.abstract | Hypersensitivity pneumonitis (HP) is mediated by Th1 immune response. NKT cells regulate immune responses by modulating the Th1/Th2 balance. Therefore, we postulated that NKT cells play a critical role in the development of the HP by modulating the Th1/Th2 response. To address this issue, we explored the functional roles of NKT cells in Saccharopolyspora rectivirgula (SR)-induced HP. In CD1d(-/-) mice, the HP was worse in terms of histological changes, hydroxyproline levels, the CD4:CD8 ratio in bronchoalveolar lavage fluid, and SR-specific immune responses than in control mice. CD1d(-/-) mice showed elevated IFN-gamma production in the lung during the HP, and this was produced mainly by Gr-1+ neutrophils. The blockade of IFN-gamma in CD1d(-/-) mice attenuated the HP, whereas the injection of rIFN-gamma aggravated it. Moreover, the depletion of Gr-1+ neutrophils reduced CD8+ T cell numbers in bronchoalveolar lavage fluid during the HP. The adoptive transfer of IL-4(-/-) mouse NKT cells did not attenuate the HP, whereas wild-type or IFN-gamma(-/-) mouse NKT cells suppressed the HP. In conclusion, NKT cells producing IL-4 play a protective role in SR-induced HP by suppressing IFN-gamma-producing neutrophils, which induce the activation and proliferation of CD8+ T cells in the lung. | en |
dc.language.iso | en | - |
dc.publisher | American Association of Immunologists | en |
dc.subject | Alveolitis, Extrinsic Allergic/*etiology/immunology/microbiology | en |
dc.subject | Animals | en |
dc.subject | Antigens, CD1 | en |
dc.subject | Antigens, CD1d | en |
dc.subject | CD8-Positive T-Lymphocytes | en |
dc.subject | Cell Proliferation | en |
dc.subject | Interferon-gamma/biosynthesis/*physiology | en |
dc.subject | Interleukin-4/*secretion | en |
dc.subject | Killer Cells, Natural/cytology/*secretion | en |
dc.subject | Lung/immunology/pathology | en |
dc.subject | Lymphocyte Activation | en |
dc.subject | Mice | en |
dc.subject | Mice, Knockout | en |
dc.subject | Neutrophils/cytology/*metabolism | en |
dc.subject | Saccharopolyspora | en |
dc.subject | T-Lymphocytes | en |
dc.subject | Cell Communication | - |
dc.title | IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황수진 | - |
dc.contributor.AlternativeAuthor | 김상희 | - |
dc.contributor.AlternativeAuthor | 박원서 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
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