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Methacholine and adenosine 5'-monophosphate challenges in children with post-infectious bronchiolitis obliterans

Cited 10 time in Web of Science Cited 12 time in Scopus
Authors
Yoo, Y.; Yu, J.; Kim, D. K.; Choi, S. H.; Kim, C. K.; Koh, Y. Y.
Issue Date
2006-01-03
Publisher
European Respiratory Society
Citation
Eur Respir J. 2006 Jan;27(1):36-41.
Keywords
Adenosine Monophosphate/*diagnostic useAnalysis of VarianceAsthma/physiopathologyBronchial Provocation Tests/*methodsBronchiolitis Obliterans/*physiopathologyCase-Control StudiesChi-Square DistributionChildFemaleHumansMaleMethacholine Chloride/*diagnostic use
Abstract
Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, but is also frequently demonstrated by children and adults with chronic obstructive lung diseases. AHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in children with post-infectious bronchiolitis obliterans (BO). Methacholine and adenosine 5'-monophosphate (AMP) challenges were used as tools for the evaluation of AHR to direct and indirect stimuli, respectively, in children with post-infectious BO (n = 28). These results were compared with those of asthmatic (n = 30) and control children (n = 25). Altogether, twenty-two patients (78.6%) with post-infectious BO were hyperreactive to methacholine with a provocative concentration causing a 20% fall in forced expiratory volume in one second (PC20) of <16 mg x mL(-1), but only six (21.4%) were hyperreactive to AMP with a PC20 of <200 mg x mL(-1). All patients with asthma responded positively to methacholine, and most (28, 93.3%) also responded positively to AMP. The majority of controls were insensitive to both challenges. Airway hyperresponsiveness to methacholine is a frequent, but by no means universal, finding in children with post-infectious bronchiolitis obliterans, but is usually not accompanied by airway hyperresponsiveness to adenosine 5'-monophosphate. This finding suggests that airway hyperresponsiveness in patients with post-infectious bronchiolitis obliterans has characteristics that differ from those of asthmatic subjects.
ISSN
0903-1936 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16387933

https://hdl.handle.net/10371/22599
DOI
https://doi.org/10.1183/09031936.06.00019605
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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