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Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Noh, K. | - |
dc.contributor.author | Lim, H. | - |
dc.contributor.author | Moon, S. K. | - |
dc.contributor.author | Kang, J. S. | - |
dc.contributor.author | Lee, W. J. | - |
dc.contributor.author | Lee, D. | - |
dc.contributor.author | Hwang, Y. I. | - |
dc.date.accessioned | 2009-12-24T11:18:59Z | - |
dc.date.available | 2009-12-24T11:18:59Z | - |
dc.date.issued | 2005-03-26 | - |
dc.identifier.citation | Immunol Lett. 2005 Apr 15;98(1):63-72. | en |
dc.identifier.issn | 0165-2478 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15790510 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22612 | - |
dc.description.abstract | Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or after being sensitized with DNFB. T cells were isolated in each group and examined. When stimulated antigen-specifically or non-specifically in vitro, mice showed elevated thymidine uptake and a shift of cytokine secretion profiles toward Th1, i.e., elevated levels IL-2, TNF-alpha, and IFN-gamma, and lowered level of the Th2 cytokine IL-4, only when Vitamin C was administered during sensitization. T cells from those mice administered Vitamin C before sensitization or after challenge showed the same T cell properties as those from PBS-treated mice. Mice were also given 0.625 mg/day of Vitamin C during primary and/or secondary immunizations with KLH and secondary specific antibody titers in sera were measured. The total specific antibody titer was lowered in Vitamin C-treated animals whenever treatments were administered, and this was entirely attributed to decreased levels of IgG1 and IgE antibodies. Based on these results, we suggest that an exogenously administered mega-dose of Vitamin C shifts immunity in Balb/c mouse toward Th1 and that these affects occur only when Vitamin C is administered during T cell activation. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Antioxidants/*pharmacology | en |
dc.subject | Ascorbic Acid/*pharmacology | en |
dc.subject | Cell Proliferation | en |
dc.subject | Cytokines/secretion | en |
dc.subject | Dinitrofluorobenzene/immunology | en |
dc.subject | Drug Hypersensitivity/immunology | en |
dc.subject | Hemocyanin/immunology | en |
dc.subject | Hypersensitivity, Delayed/chemically induced/immunology | en |
dc.subject | Immunoglobulin E/immunology | en |
dc.subject | Immunoglobulin G/immunology | en |
dc.subject | Inflammation/drug therapy | en |
dc.subject | Lymphocyte Activation/*drug effects/immunology | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | T-Lymphocytes/*drug effects/immunology/secretion | en |
dc.subject | Time Factors | en |
dc.title | Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임현자 | - |
dc.contributor.AlternativeAuthor | 문성규 | - |
dc.contributor.AlternativeAuthor | 강재승 | - |
dc.contributor.AlternativeAuthor | 이왕재 | - |
dc.contributor.AlternativeAuthor | 이동섭 | - |
dc.contributor.AlternativeAuthor | 황영일 | - |
dc.identifier.doi | 10.1016/j.imlet.2004.10.012 | - |
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