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Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation

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dc.contributor.authorNoh, K.-
dc.contributor.authorLim, H.-
dc.contributor.authorMoon, S. K.-
dc.contributor.authorKang, J. S.-
dc.contributor.authorLee, W. J.-
dc.contributor.authorLee, D.-
dc.contributor.authorHwang, Y. I.-
dc.date.accessioned2009-12-24T11:18:59Z-
dc.date.available2009-12-24T11:18:59Z-
dc.date.issued2005-03-26-
dc.identifier.citationImmunol Lett. 2005 Apr 15;98(1):63-72.en
dc.identifier.issn0165-2478 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15790510-
dc.identifier.urihttps://hdl.handle.net/10371/22612-
dc.description.abstractPreviously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or after being sensitized with DNFB. T cells were isolated in each group and examined. When stimulated antigen-specifically or non-specifically in vitro, mice showed elevated thymidine uptake and a shift of cytokine secretion profiles toward Th1, i.e., elevated levels IL-2, TNF-alpha, and IFN-gamma, and lowered level of the Th2 cytokine IL-4, only when Vitamin C was administered during sensitization. T cells from those mice administered Vitamin C before sensitization or after challenge showed the same T cell properties as those from PBS-treated mice. Mice were also given 0.625 mg/day of Vitamin C during primary and/or secondary immunizations with KLH and secondary specific antibody titers in sera were measured. The total specific antibody titer was lowered in Vitamin C-treated animals whenever treatments were administered, and this was entirely attributed to decreased levels of IgG1 and IgE antibodies. Based on these results, we suggest that an exogenously administered mega-dose of Vitamin C shifts immunity in Balb/c mouse toward Th1 and that these affects occur only when Vitamin C is administered during T cell activation.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAnimalsen
dc.subjectAntioxidants/*pharmacologyen
dc.subjectAscorbic Acid/*pharmacologyen
dc.subjectCell Proliferationen
dc.subjectCytokines/secretionen
dc.subjectDinitrofluorobenzene/immunologyen
dc.subjectDrug Hypersensitivity/immunologyen
dc.subjectHemocyanin/immunologyen
dc.subjectHypersensitivity, Delayed/chemically induced/immunologyen
dc.subjectImmunoglobulin E/immunologyen
dc.subjectImmunoglobulin G/immunologyen
dc.subjectInflammation/drug therapyen
dc.subjectLymphocyte Activation/*drug effects/immunologyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectT-Lymphocytes/*drug effects/immunology/secretionen
dc.subjectTime Factorsen
dc.titleMega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activationen
dc.typeArticleen
dc.contributor.AlternativeAuthor임현자-
dc.contributor.AlternativeAuthor문성규-
dc.contributor.AlternativeAuthor강재승-
dc.contributor.AlternativeAuthor이왕재-
dc.contributor.AlternativeAuthor이동섭-
dc.contributor.AlternativeAuthor황영일-
dc.identifier.doi10.1016/j.imlet.2004.10.012-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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