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Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, K. O. | - |
dc.contributor.author | Kang, H. | - |
dc.contributor.author | Shin, S. M. | - |
dc.contributor.author | Cho, K. H. | - |
dc.contributor.author | Kwon, B. | - |
dc.contributor.author | Kwon, B. S. | - |
dc.contributor.author | Kim, S. J. | - |
dc.contributor.author | Lee, H. W. | - |
dc.date.accessioned | 2009-12-24T11:20:17Z | - |
dc.date.available | 2009-12-24T11:20:17Z | - |
dc.date.issued | 2005-02-09 | - |
dc.identifier.citation | J Immunol. 2005 Feb 15;174(4):1898-905. | en |
dc.identifier.issn | 0022-1767 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15699116 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22613 | - |
dc.description.abstract | Cross-linking of 4-1BB, a member of the TNFR family, increased tyrosine phosphorylation of TCR-signaling molecules such as CD3epsilon, CD3zeta, Lck, the linker for activation of T cells, and SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76). In addition, incubation of activated CD8+ T cells with p815 cells expressing 4-1BBL led to redistribution of the lipid raft domains and Lck, protein kinase C-theta;, SLP-76, and phospholipase C-gamma1 (PLC-gamma1) on the T cell membranes to the areas of contact with the p815 cells and recruitment of 4-1BB, TNFR-associated factor 2, and phospho-tyrosine proteins to the raft domains. 4-1BB ligation also caused translocation of TNFR-associated factor 2, protein kinase C-theta;, PLC-gamma1, and SLP-76 to detergent-insoluble compartments in the CD8+ T cells, and cross-linking of 4-1BB increased intracellular Ca2+ levels apparently by activating PLC-gamma1. The redistribution of lipid rafts and Lck, as well as translocation of PLC-gamma1, and degradation of IkappaB-alpha in response to 4-1BB were inhibited by disrupting the formation of lipid rafts with methyl-beta-cyclodextrin. These findings demonstrate that 4-1BB is a T cell costimulatory receptor that activates TCR-signaling pathways in CD8+ T cells. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.subject | 4-1BB Ligand | en |
dc.subject | Animals | en |
dc.subject | Antibodies, Monoclonal/metabolism | en |
dc.subject | Antigens, CD | en |
dc.subject | Antigens, CD137 | en |
dc.subject | CD8-Positive T-Lymphocytes/drug effects/enzymology/*immunology/*metabolism | en |
dc.subject | Calcium/metabolism | en |
dc.subject | Cetomacrogol | en |
dc.subject | Cyclosporine/pharmacology | en |
dc.subject | Detergents | en |
dc.subject | Growth Inhibitors/pharmacology | en |
dc.subject | Intracellular Fluid/metabolism | en |
dc.subject | Ligands | en |
dc.subject | Lymphocyte Activation/drug effects/*immunology | en |
dc.subject | Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism | en |
dc.subject | Membrane Microdomains/enzymology/metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | Phosphotyrosine/metabolism | en |
dc.subject | Protein Transport/immunology | en |
dc.subject | Pyrimidines/pharmacology | en |
dc.subject | Receptors, Antigen, T-Cell/metabolism/*physiology | en |
dc.subject | Receptors, Nerve Growth Factor/antagonists & | en |
dc.subject | inhibitors/*immunology/*metabolism/physiology | en |
dc.subject | Receptors, Tumor Necrosis Factor/antagonists & | en |
dc.subject | inhibitors/*immunology/*metabolism/physiology | en |
dc.subject | Signal Transduction/drug effects/*immunology | en |
dc.subject | Solubility | en |
dc.subject | TNF Receptor-Associated Factor 2/metabolism | en |
dc.subject | Tumor Necrosis Factor-alpha/metabolism | en |
dc.subject | beta-Cyclodextrins/pharmacology | en |
dc.title | Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 남경옥 | - |
dc.contributor.AlternativeAuthor | 강현 | - |
dc.contributor.AlternativeAuthor | 신수미 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.contributor.AlternativeAuthor | 권병석 | - |
dc.contributor.AlternativeAuthor | 김성진 | - |
dc.contributor.AlternativeAuthor | 이현우 | - |
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