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The effect of tiarellic acid on the expressions of matrix metalloproteinase-1 and type 1 procollagen in ultraviolet irradiated cultured human skin fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, H. I. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Eun, H. C. | - |
dc.contributor.author | Kim, K. H. | - |
dc.contributor.author | Chung, J. H. | - |
dc.date.accessioned | 2009-12-24T11:20:43Z | - |
dc.date.available | 2009-12-24T11:20:43Z | - |
dc.date.issued | 2005-03-15 | - |
dc.identifier.citation | J Ethnopharmacol. 2005 Apr 8;98(1-2):185-9. | en |
dc.identifier.issn | 0378-8741 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15763381 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22614 | - |
dc.description.abstract | Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of tiarellic acid on the expressions of MMP-1 and type 1 procollagen in ultraviolet irradiation of cultured human skin fibroblasts. Tiarellic acid reduced the expression of MMP-1 and induced the expression of type 1- procollagen at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that tiarellic acid plays an important role in the reduction of MMP-1 and induction of type 1- procollagen by ultraviolet irradiation. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Catechin/analogs & derivatives/pharmacology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Collagen Type I/*drug effects/genetics/radiation effects | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Fibroblasts/*drug effects/radiation effects | en |
dc.subject | Gene Expression/drug effects/genetics | en |
dc.subject | Humans | en |
dc.subject | Matrix Metalloproteinase 1/antagonists & inhibitors/*drug | en |
dc.subject | effects/radiation effects | en |
dc.subject | Plants, Medicinal/chemistry | en |
dc.subject | Skin/drug effects/pathology/radiation effects | en |
dc.subject | Time Factors | en |
dc.subject | Triterpenes/chemistry/isolation & purification/*pharmacology | en |
dc.subject | Ultraviolet Rays/*adverse effects | en |
dc.title | The effect of tiarellic acid on the expressions of matrix metalloproteinase-1 and type 1 procollagen in ultraviolet irradiated cultured human skin fibroblasts | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문형인 | - |
dc.contributor.AlternativeAuthor | 이중구 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1016/j.jep.2005.01.027 | - |
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