S-Space College of Medicine/School of Medicine (의과대학/대학원) Immunology (면역학전공) Journal Papers (저널논문_면역학전공)
Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice
- Kim, H. H.; Lee, M. J.; Lee, S. R.; Kim, K. H.; Cho, K. H.; Eun, H. C.; Chung, J. H.
- Issue Date
- Mech Ageing Dev. 2005 Nov;126(11):1170-7.
- Animals; Female; Humans; *Infrared Rays; Mice; *Mice, Hairless; *Skin/anatomy & histology/pathology/radiation effects; Skin Aging/pathology/*radiation effects; *Ultraviolet Rays
- Skin aging can be divided into intrinsic aging and photoaging. Sunlight is a major cause of photoaging, and is composed of ultraviolet (UV) and infrared (IR) radiation. Although the effects of UV radiation on skin aging have been widely studied, little is known about the biological effects of IR on the photoaging process in human skin. We found that chronic IR treatment induced wrinkles in hairless mice, and augments UV-induced wrinkle formation and UV-induced skin thickening in hairless mice. Histologically, we found that IR treatment augments UV-induced epidermal and dermal thickening, and that UV-induced increases of collagen and elastic fibers in dermis. Moreover, chronic IR treatment increased MMP-3 and MMP-13 mRNA expressions significantly in hairless mouse skin and augmented UV-induced MMP-3 and MMP-13 mRNA expressions and UV-induced MMP-2 and MMP-9 activities. From these results, we demonstrate that IR alone induces skin wrinkling and augments UV-induced wrinkle formation. Taken together, we suggest that IR plays an important role in the development of photoaging.
- 0047-6374 (Print)
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