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Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice

Cited 77 time in Web of Science Cited 85 time in Scopus
Authors
Kim, H. H.; Lee, M. J.; Lee, S. R.; Kim, K. H.; Cho, K. H.; Eun, H. C.; Chung, J. H.
Issue Date
2005-08-25
Publisher
Elsevier
Citation
Mech Ageing Dev. 2005 Nov;126(11):1170-7.
Keywords
AnimalsFemaleHumans*Infrared RaysMice*Mice, Hairless*Skin/anatomy & histology/pathology/radiation effectsSkin Aging/pathology/*radiation effects*Ultraviolet Rays
Abstract
Skin aging can be divided into intrinsic aging and photoaging. Sunlight is a major cause of photoaging, and is composed of ultraviolet (UV) and infrared (IR) radiation. Although the effects of UV radiation on skin aging have been widely studied, little is known about the biological effects of IR on the photoaging process in human skin. We found that chronic IR treatment induced wrinkles in hairless mice, and augments UV-induced wrinkle formation and UV-induced skin thickening in hairless mice. Histologically, we found that IR treatment augments UV-induced epidermal and dermal thickening, and that UV-induced increases of collagen and elastic fibers in dermis. Moreover, chronic IR treatment increased MMP-3 and MMP-13 mRNA expressions significantly in hairless mouse skin and augmented UV-induced MMP-3 and MMP-13 mRNA expressions and UV-induced MMP-2 and MMP-9 activities. From these results, we demonstrate that IR alone induces skin wrinkling and augments UV-induced wrinkle formation. Taken together, we suggest that IR plays an important role in the development of photoaging.
ISSN
0047-6374 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16118013

http://hdl.handle.net/10371/22630
DOI
https://doi.org/10.1016/j.mad.2005.06.003
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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