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Increased expression of 14-3-3varepsilon protein in intrinsically aged and photoaged human skin in vivo

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dc.contributor.authorChoi, K. C.-
dc.contributor.authorLee, S.-
dc.contributor.authorKwak, S. Y.-
dc.contributor.authorKim, M. S.-
dc.contributor.authorChoi, H. K.-
dc.contributor.authorKim, K. H.-
dc.contributor.authorChung, J. H.-
dc.contributor.authorPark, S. H.-
dc.date.accessioned2009-12-24T11:57:15Z-
dc.date.available2009-12-24T11:57:15Z-
dc.date.issued2005-05-13-
dc.identifier.citationMech Ageing Dev. 2005 Jun-Jul;126(6-7):629-36. Epub 2005 Jan 21.en
dc.identifier.issn0047-6374 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15888315-
dc.identifier.urihttps://hdl.handle.net/10371/22646-
dc.description.abstractSkin aging is a complicated process associated with the passage of time and environmental exposure, especially to UV light. This aging phenomenon is related to alterations in various cellular mechanisms, such as changes in apoptosis, perturbations to cellular signaling, and an increased genetic instability. In this study, we investigated changes of proteins involved in intrinsic aging by the proteomic analysis of human sun-protected (upper inner arm) young and aged dermis. One of the proteins upregulated in aged dermis was identified as 14-3-3epsilon. This protein is an isoform of 14-3-3 protein, which is involved in cellular processes like signal transduction, cell cycle arrest, and apoptosis. 14-3-3epsilon is consistently found to be upregulated in the sun-protected dermis of aged skin, by Western blotting and immunohistochemical staining. In addition, we demonstrate that the expression of 14-3-3epsilon is further upregulated in the sun-exposed (photodamaged) dermis, and that the UV irradiation of young skin significantly upregulates 14-3-3epsilon in vivo. Our results suggest the possibility that the cellular processes related to 14-3-3epsilon protein play an important role in the photoaging and intrinsic aging of human skin.en
dc.language.isoen-
dc.publisherElsevieren
dc.subject14-3-3 Proteins/*biosynthesisen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectDermis/*metabolism/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSkin Aging/pathology/*physiology/radiation effectsen
dc.subjectUltraviolet Rays/adverse effectsen
dc.titleIncreased expression of 14-3-3varepsilon protein in intrinsically aged and photoaged human skin in vivoen
dc.typeArticleen
dc.contributor.AlternativeAuthor최경철-
dc.contributor.AlternativeAuthor이세라-
dc.contributor.AlternativeAuthor곽선영-
dc.contributor.AlternativeAuthor김미선-
dc.contributor.AlternativeAuthor최호경-
dc.contributor.AlternativeAuthor김규한-
dc.contributor.AlternativeAuthor정진호-
dc.contributor.AlternativeAuthor박석희-
dc.identifier.doi10.1016/j.mad.2004.11.013-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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