Browse

A hybrid systems framework for cellular processes

Cited 17 time in Web of Science Cited 18 time in Scopus
Authors
Cho, K. H.; Johansson, K. H.; Wolkenhauer, O.
Issue Date
2005-05-13
Publisher
Elsevier
Citation
Biosystems. 2005 Jun;80(3):273-82. Epub 2005 Jan 15.
Keywords
AlgorithmsAnimalsCell DifferentiationComputational Biology/*methodsComputers*CytologyHumansMAP Kinase Signaling SystemMacromolecular SubstancesModels, BiologicalModels, StatisticalModels, TheoreticalProtein Structure, TertiarySignal TransductionSoftwareSystems BiologySystems TheoryTime Factors
Abstract
With the availability of technologies that allow us to obtain stimulus-response time series data for modeling and system identification, there is going to be an increasing need for conceptual frameworks in which to formulate and test hypotheses about intra- and inter-cellular dynamics, in general and not just dependent on a particular cell line, cell type, organism, or technology. While the semantics can be quite different, biologists and systems scientists use in many cases a similar language (notion of feedback, regulation, etc.). A more abstract system-theoretic framework for signals, systems, and control could provide the biologist with an interface between the domains. Apart from recent examples to identify functional elements and describing them in engineering terms, there have been various more abstract developments to describe dynamics at the cell level in the past. This includes Rosen's (M,R)-systems. This paper presents an abstract and general compact mathematical framework of intracellular dynamics, regulation and regime switching inspired by (M,R)-theory and based on hybrid automata.
ISSN
0303-2647 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15888342

http://hdl.handle.net/10371/22650
DOI
https://doi.org/10.1016/j.biosystems.2004.12.002
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse