Browse

Acute intestinal pseudo-obstruction after induction treatment of relapsed acute promyelocytic leukemia with arsenic trioxide

Cited 1 time in Web of Science Cited 1 time in Scopus
Issue Date
2007-07-20
Publisher
Wiley-Blackwell
Citation
Pediatr Blood Cancer. 2008 Apr;50(4):872-4.
Keywords
Antineoplastic Agents/*adverse effectsArsenicals/*adverse effectsChildDigestive System Surgical ProceduresFemaleHumansIntestinal Pseudo-Obstruction/*chemically induced/*pathology/surgeryLeukemia, Promyelocytic, Acute/*drug therapyNeoplasm Recurrence, Local/drug therapyOxides/*adverse effects
Abstract
Arsenic trioxide (As(2)O(3)) is an effective agent for the treatment of relapsed acute promyelocytic leukemia (APL). We report a patient with intestinal pseudo-obstruction, which occurred while treating relapsed APL with As(2)O(3). A 6-year-old female with relapsed APL developed paralytic ileus, hyperleukocytosis, and a high fever while being treated with As(2)O(3). Although As(2)O(3) was discontinued and dexamethasone was administered, vomiting and abdominal distension worsened. An ileostomy was performed and diffuse patch-like infiltrations on the bowel surface were noted. Pathologic findings revealed APL cells involving the entire intestinal layers. This case history suggests that As(2)O(3) when used for reinduction therapy for APL may adversely affect the intestine and cause acute intestinal pseudo-obstruction.
ISSN
1545-5017 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17635008

https://hdl.handle.net/10371/22858
DOI
https://doi.org/10.1002/pbc.21302
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse