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Cortical thinning in obsessive compulsive disorder

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dc.contributor.authorShin, Yong-Wook-
dc.contributor.authorYoo, So Young-
dc.contributor.authorLee, Jun Ki-
dc.contributor.authorHa, Tae Hyon-
dc.contributor.authorLee, Kyung Jin-
dc.contributor.authorLee, Jong Min-
dc.contributor.authorKim, In Young-
dc.contributor.authorKim, Sun I-
dc.contributor.authorKwon, Jun Soo-
dc.date.accessioned2009-12-28T09:04:18Z-
dc.date.available2009-12-28T09:04:18Z-
dc.date.issued2007-05-26-
dc.identifier.citationHum Brain Mapp. 2007 Nov;28(11):1128-35.en
dc.identifier.issn1065-9471 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17525985-
dc.identifier.urihttps://hdl.handle.net/10371/22874-
dc.description.abstractAlthough studies of obsessive-compulsive disorder (OCD) over the last 20 years have suggested abnormalities in frontal-subcortical circuitry, evidences of structural abnormalities in those areas are still imperfect and contradictory. With recent advances in neuroimaging technology, it is now possible to study cortical thickness based on cortical surfaces, which offers a direct quantitative index of cortical mass. Using the constrained Laplacian-based automated segmentation with proximities (CLASP) algorithm, we measured cortical thickness of 55 patients with OCD (33 men and 22 women) and 52 age- and sex-matched healthy volunteers (32 men and 20 women). We found multiple regions of cortical thinning in OCD patients compared to the normal control group. Patients with OCD had thinner left inferior frontal, left middle frontal, left precentral, left superior temporal, left parahippocampal, left orbitofrontal, and left lingual cortices. Most thinned regions were located in the left ventral cortex system, providing a new perspective that this ventral cortical system may be involved in the pathophysiology of OCD.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectAtrophy/etiology/*pathology/physiopathologyen
dc.subjectBrain Mappingen
dc.subjectCerebral Cortex/*pathology/physiopathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisteden
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectNeurodegenerative Diseases/*pathology/physiopathologyen
dc.subjectObsessive-Compulsive Disorder/*pathology/physiopathologyen
dc.subjectPredictive Value of Testsen
dc.subjectPrefrontal Cortex/pathology/physiopathologyen
dc.subjectTemporal Lobe/pathology/physiopathologyen
dc.titleCortical thinning in obsessive compulsive disorderen
dc.typeArticleen
dc.contributor.AlternativeAuthor신용욱-
dc.contributor.AlternativeAuthor유소영-
dc.contributor.AlternativeAuthor이준기-
dc.contributor.AlternativeAuthor하태현-
dc.contributor.AlternativeAuthor이경진-
dc.contributor.AlternativeAuthor이종민-
dc.contributor.AlternativeAuthor김인영-
dc.contributor.AlternativeAuthor권준수-
dc.identifier.doi10.1002/hbm.20338-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Clinical Pharmacology (협동과정-임상약리학전공)Journal Papers (저널논문_협동과정-임상약리학전공)
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