Browse

Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Kim, Dae-Sung; Lee, Moo-Song; Kim, Young-Sik; Kim, Dong-Hyun; Bae, Jong-Myon; Shin, Myung-Hee; Ahn, Yoon-Ok
Issue Date
2005-03-11
Publisher
Springer Verlag
Citation
Eur J Epidemiol. 2005;20(1):67-71.
Keywords
AdultAscorbic Acid/*administration & dosageCase-Control StudiesFemaleHelicobacter pylori/immunology/*isolation & purificationHumansImmunoglobulin G/bloodKoreaMaleMiddle AgedQuestionnairesSeroepidemiologic StudiesStomach Neoplasms/*microbiology
Abstract
A hospital-based case-control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between Helicobacter pylori infection and gastric cancer in Korea in 1997-1998. Anti-H. pylori IgG was detected by ELISA. A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered. The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI): 1.14, 2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer. In a stratified analysis, H. pylori seropositivity was found to be a significant risk factor for gastric cancer in the low vitamin C intake group (OR = 4.68; 95% CI: 1.97, 11.1), but not in the high vitamin C intake group (OR = 0.72; 95% CI: 0.32, 1.65). Vitamin C intake was found to modify the relation between H. pylori and gastric cancer.
ISSN
0393-2990 (Print)
Language
English
URI
http://hdl.handle.net/10371/22879
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse