S-Space College of Medicine/School of Medicine (의과대학/대학원) Preventive Medicine (예방의학전공) Journal Papers (저널논문_예방의학전공)
Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori
- Kim, Dae-Sung; Lee, Moo-Song; Kim, Young-Sik; Kim, Dong-Hyun; Bae, Jong-Myon; Shin, Myung-Hee; Ahn, Yoon-Ok
- Issue Date
- Springer Verlag
- Eur J Epidemiol. 2005;20(1):67-71.
- Adult; Ascorbic Acid/*administration & dosage; Case-Control Studies; Female; Helicobacter pylori/immunology/*isolation & purification; Humans; Immunoglobulin G/blood; Korea; Male; Middle Aged; Questionnaires; Seroepidemiologic Studies; Stomach Neoplasms/*microbiology
- A hospital-based case-control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between Helicobacter pylori infection and gastric cancer in Korea in 1997-1998. Anti-H. pylori IgG was detected by ELISA. A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered. The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI): 1.14, 2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer. In a stratified analysis, H. pylori seropositivity was found to be a significant risk factor for gastric cancer in the low vitamin C intake group (OR = 4.68; 95% CI: 1.97, 11.1), but not in the high vitamin C intake group (OR = 0.72; 95% CI: 0.32, 1.65). Vitamin C intake was found to modify the relation between H. pylori and gastric cancer.
- 0393-2990 (Print)
- Files in This Item: There are no files associated with this item.