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A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naive first-episode mania

Cited 49 time in Web of Science Cited 52 time in Scopus
Issue Date
2007
Publisher
Wiley-Blackwell
Citation
Bipolar Disord 2007; 9: 693-697
Keywords
AdultAge FactorsAnticonvulsants/therapeutic useAntipsychotic Agents/therapeutic useBipolar Disorder/diagnosis/drug therapy/*pathologyBrain/*pathologyBrain Mapping/methodsDiagnostic and Statistical Manual of Mental DisordersFemaleFunctional Laterality/*physiologyGyrus Cinguli/pathologyHumansMagnetic Resonance Imaging/*statistics & numerical dataMalePsychiatric Status Rating ScalesSex Factors
Abstract
OBJECTIVES: Patients with bipolar disorder have changes in brain structures but it is unclear if these are present at disease onset and thus predispose subjects to develop the disorder, or whether they develop during the course of the disorder, either due to the effects of multiple episodes or as a consequence of treatment with psychotropic agents. Studies in first-episode (FE) manic patients have the potential to provide answers to these questions. METHODS: Voxel-based morphometry (VBM) was used to assess magnetic resonance imaging scans of 15 FE manic patients and 15 matched healthy controls. RESULTS: Using a priori defined statistical criteria, no significant differences in brain structures were noted between the two groups. However, there was approximately a 6% reduction in left anterior cingulate, left precuneus and right posterior cingulate volume in FE patients and these reductions were significant (p
ISSN
1398-5647 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17988358

https://hdl.handle.net/10371/23168
DOI
https://doi.org/10.1111/j.1399-5618.2007.00414.x
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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