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Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study

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dc.contributor.authorSung, Young Hoon-
dc.contributor.authorCho, Soo Churl-
dc.contributor.authorHwang, Jaeuk-
dc.contributor.authorKim, Seog Ju-
dc.contributor.authorKim, Hyungjun-
dc.contributor.authorBae, Sujin-
dc.contributor.authorKim, Namguk-
dc.contributor.authorChang, Kee Hyun-
dc.contributor.authorDaniels, Melissa-
dc.contributor.authorRenshaw, Perry F-
dc.contributor.authorLyoo, In Kyoon-
dc.date.accessioned2009-12-29T07:24:33Z-
dc.date.available2009-12-29T07:24:33Z-
dc.date.issued2007-
dc.identifier.citationDrug Alcohol Depend. 88, 28-35en
dc.identifier.issn0376-8716 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17084995-
dc.identifier.urihttps://hdl.handle.net/10371/23176-
dc.description.abstractOBJECTIVE: Altered concentrations of the brain metabolites, including N-acetyl-aspartate (NAA) and myo-inositol (MI), may indicate neurotoxicity associated with drug abuse. In this study, the authors explored differences in brain metabolites between abstinent methamphetamine (MA) abusers and healthy comparison subjects and the associations between metabolite concentrations and clinical characteristics. METHOD: Proton magnetic resonance spectroscopy (MRS) was performed on 30 abstinent MA abusers and 20 healthy comparison subjects. Two sets of MA user subgroups were defined depending on abstinence duration (greater or less than 6 months) or the total cumulative MA dose (greater or less than 100 g lifetime). NAA and other metabolites were measured in the frontal gray and white matter and compared between MA abuser groups and healthy comparison subjects. RESULTS: MI concentrations were higher for the MA abusers relative to healthy comparison subjects. NAA concentration was lower in frontal white matter of MA abusers with a 'large' cumulative dose relative to those with a 'small' cumulative dose and to healthy comparison subjects. Additionally, in MA abusers NAA concentrations in frontal white matter correlated inversely with the cumulative MA dose. In contrast, there was no significant difference in frontal gray matter NAA concentration among the three groups. However, frontal gray matter NAA concentrations for MA abusers correlated negatively with the total cumulative MA dose and positively with the duration of abstinence. There were no differences between the different MA user groups for MI. CONCLUSIONS: The current findings suggest that MA-induced metabolic alterations of frontal gray and white matter are dose-dependent, for primarily male subjects. Additionally, these findings potentially suggest that the MA-related abnormalities may, in part, recover with abstinence in gray matter, but not in the white matter regions.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAmphetamine-Related Disorders/*metabolism/*pathologyen
dc.subjectAnalysis of Varianceen
dc.subjectAspartic Acid/*analogs & derivatives/analysisen
dc.subjectBasal Ganglia/pathologyen
dc.subjectCholine/analysisen
dc.subjectCreatine/analysisen
dc.subjectFrontal Lobe/pathologyen
dc.subjectInositol/analysisen
dc.subjectKoreaen
dc.subjectMethamphetamine/*adverse effectsen
dc.subjectNeurotoxins/metabolismen
dc.subjectProtonsen
dc.subjectTime Factorsen
dc.subjectMagnetic Resonance Spectroscopy-
dc.titleRelationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy studyen
dc.typeArticleen
dc.contributor.AlternativeAuthor성영훈-
dc.contributor.AlternativeAuthor조수철-
dc.contributor.AlternativeAuthor황재욱-
dc.contributor.AlternativeAuthor김석주-
dc.contributor.AlternativeAuthor김형준-
dc.contributor.AlternativeAuthor배수진-
dc.contributor.AlternativeAuthor김남국-
dc.contributor.AlternativeAuthor장기현-
dc.contributor.AlternativeAuthor류인균-
dc.identifier.doi10.1016/j.drugalcdep.2006.09.011-
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