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Remifentanil halves the EC50 of propofol for successful insertion of the laryngeal mask airway and laryngeal tube in pediatric patients

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dc.contributor.authorPark, Hye-Jin-
dc.contributor.authorLee, Jeong-Rim-
dc.contributor.authorKim, Chong Sung-
dc.contributor.authorKim, Seong Deok-
dc.contributor.authorKim, Hee-Soo-
dc.date.accessioned2009-12-30-
dc.date.available2009-12-30-
dc.date.issued2007-07-01-
dc.identifier.citationAnesth Analg 2007;105:57-61en
dc.identifier.issn1526-7598 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17578957-
dc.identifier.urihttps://hdl.handle.net/10371/23395-
dc.description.abstractBACKGROUND: Propofol and remifentanil are the drugs of choice for insertion of the supraglottic airway without muscle relaxants for short duration surgery. In this study, we compared propofol concentrations required for insertion of laryngeal mask way (LMA) or laryngeal tube (LT) with and without remifentanil. METHODS: We included children scheduled for surgeries lasting <2 h, and assigned them to four groups in a randomized, double-blind manner: LMA with propofol + saline (LMA-P), LT with propofol + saline (LT-P), LMA with propofol + 7.5 ng/mL remifentanil (LMA-PR), LT with propofol +7.5 ng/mL remifentanil (LT-PR). Anesthesia was conducted by target-controlled infusion in determined target effect site concentration of propofol and remifentanil with the STELPUMP program. The EC50 of propofol for airway device placement was determined using Dixon's up-and-down method. The concentration of propofol for consecutive patients in each group was determined by the response of the previous patient, using increments or decrements of 0.2 microg/mL. RESULTS: In patients receiving remifentanil, propofol EC50 for insertion of a LMA was 2.57 +/- 0.22 microg/mL and that of LT was 2.59 +/- 0.20 microg/mL (n.s.). In patients receiving saline, the corresponding values were 5.45 +/- 0.21 microg/mL and 5.58 +/- 0.23 microg/mL (n.s.). Conditions were excellent in 64% (9 of 14) and 79% (11 of 14) of patients receiving remifentanil, but in patients receiving saline, the values were 18% (2 of 11) for the LMA and 40.0% (4 of 10) for the LT. CONCLUSIONS: Remifentanil 7.5 ng/mL reduced the propofol concentration required for airway insertion by half, and improved conditions for insertion. Propofol concentrations for insertion of the LMA and LT were similar.en
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkinsen
dc.subjectAge Factorsen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDouble-Blind Methoden
dc.subjectHumansen
dc.subjectIntubation, Intratracheal/methodsen
dc.subject*Laryngeal Masksen
dc.subjectLarynx/drug effects/metabolismen
dc.subjectPiperidines/*administration & dosage/pharmacokineticsen
dc.subjectPropofol/*administration & dosage/pharmacokineticsen
dc.titleRemifentanil halves the EC50 of propofol for successful insertion of the laryngeal mask airway and laryngeal tube in pediatric patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박혜진-
dc.contributor.AlternativeAuthor이정림-
dc.contributor.AlternativeAuthor김종성-
dc.contributor.AlternativeAuthor김성덕-
dc.contributor.AlternativeAuthor김희수-
dc.identifier.doi10.1213/01.ane.0000266447.23037.e4-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
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