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Oxidative stress in pregnant women and birth weight reduction

Cited 93 time in Web of Science Cited 103 time in Scopus
Authors
Kim, Young-Ju; Hong, Yun-Chul; Lee, Kwan-Hee; Park, Heon Joo; Park, Eun Ae; Moon, Hye-Sung; Ha, Eun-Hee
Issue Date
2005-03-08
Publisher
Elsevier
Citation
Reprod Toxicol 2005;19:487-92
Keywords
AdultBiological Markers/urineBirth Weight/physiologyDeoxyguanosine/*analogs & derivatives/urineFemaleGestational AgeHumans*Infant, Low Birth Weight/urineInfant, NewbornLinear ModelsMalondialdehyde/urine*Oxidative StressPregnancy
Abstract
The purpose of this study is to evaluate the role of maternal oxidative stress in lowering neonatal birth weight. Women (N=261) with singleton pregnancy were analyzed for biomarker levels of oxidative stress after recruitment at the time of hospitalization for delivery in Korea between 2000 and 2001. Among the neonates, 247 births were full-term infants and 14 births were pre-term infants. Biomarkers measured for oxidative stress were maternal urinary 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA). The women with pre-term infants had higher concentrations of urinary 8-OH-dG and MDA than those with full-term babies. The concentrations of maternal urinary 8-OH-dG and MDA were inversely associated with birth weight of full-term deliveries after adjusting for potential confounders including maternal age, body mass index, dietary intake, alcohol consumption, smoking exposure, occupational status, and neonatal sex (P<0.05). This study demonstrates that increase of 8-OH-dG and MDA concentrations in urine of pregnant women were associated with reduced birth weight in full-term deliveries.
ISSN
0890-6238 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15749262

https://hdl.handle.net/10371/23406
DOI
https://doi.org/10.1016/j.reprotox.2004.10.007
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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