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DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | Nam, Su Youn | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Lee, Jong Yeul | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2009-12-30T01:53:51Z | - |
dc.date.available | 2009-12-30T01:53:51Z | - |
dc.date.issued | 2008-01-29 | - |
dc.identifier.citation | Exp Biol Med (Maywood) 233:180-191, 2008 | en |
dc.identifier.issn | 1535-3702 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18222973 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23416 | - |
dc.description.abstract | Previously, we have shown that DA-6034, a synthetic derivative of flavonoid eupatilin, inhibited NF-kappaB activation in colon epithelial cells and prevented trinitrobenzene sulfonic acid-induced rat colitis. The aim of this study was to investigate the preventive and therapeutic effect of DA-6034 on dextran sulfate sodium (DSS)-induced colitis and on inflammation-related cancer. C57BL/6 mice were given 4% DSS for 5 days with and without DA-6034 in the acute preventive model. In the acute therapeutic model, mice were given 4% DSS for 5 days followed by rectal administration of DA-6034. Colitis was quantified by body weight, disease activity index (DAI), colon length, and histology. In the inflammation-related cancer model, mice were given a single intraperitoneal injection of azoxymethane, then three cycles of 2% DSS for 5 days, then 2 weeks of free water consumption. Apoptosis was determined by in situ terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay, and the expression of Ki-67, phospho-kappaB kinase alpha (IKKalpha), and COX-2 were evaluated by immunohistochemistry. In both the acute preventive and acute therapeutic models, DA-6034 significantly attenuated DSS-induced weight loss, an increase in DAI, and a shortening of colon length. DA-6034-treated mice maintained crypt architecture and revealed a scanty infiltration of inflammatory cells in both the preventive and therapeutic models. In the inflammation-related cancer model, DA-6034 reduced the number of colon tumors and ameliorated weight loss and shortening of colon length. DA-6034 strongly enhanced apoptosis and inhibited the expression of COX-2 and phospho-IKKalpha in inflammation-related colon cancer models. Our results suggest that DA-6034 prevents acute murine colitis and inhibits inflammation-related colon carcinogenesis. DA-6034 could be a potential therapeutic agent for inflammatory bowel disease. | en |
dc.language.iso | en | en |
dc.publisher | Society for Experimental Biology and Medicine | en |
dc.subject | Acute Disease | en |
dc.subject | Animals | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Body Weight/drug effects | en |
dc.subject | Cell Transformation, Neoplastic | en |
dc.subject | Colitis/*chemically induced/complications/enzymology/*prevention & control | en |
dc.subject | Colonic Neoplasms/complications/pathology/*prevention & control | en |
dc.subject | Cyclooxygenase 2/metabolism | en |
dc.subject | Dextran Sulfate/*pharmacology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Flavonoids/*pharmacology | en |
dc.subject | I-kappa B Kinase/metabolism | en |
dc.subject | Ki-67 Antigen/metabolism | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Phosphorylation/drug effects | en |
dc.title | DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 남수연 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.contributor.AlternativeAuthor | 이종열 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.3181/0707-RM-186 | - |
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