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Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children

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dc.contributor.authorKim, Nam-Hee-
dc.contributor.authorLee, Jina-
dc.contributor.authorLee, Sang Jeong-
dc.contributor.authorLee, Hyunju-
dc.contributor.authorKim, Kyung-Hyo-
dc.contributor.authorPark, Su-Eun-
dc.contributor.authorLee, Hoan-Jong-
dc.date.accessioned2009-12-30T02:03:09Z-
dc.date.available2009-12-30T02:03:09Z-
dc.date.issued2007-10-13-
dc.identifier.citationVaccine 2007;25(45):7858-65en
dc.identifier.issn0264-410X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17931753-
dc.identifier.urihttps://hdl.handle.net/10371/23423-
dc.description.abstractThis study was conducted to determine the immunogenicity and safety of a 7-valent CRM197 protein conjugated pneumococcal vaccine (PCV7) in Korean infants immunized at 2, 4 and 6 months. A total of 202 infants were enrolled and 146 and 141 infants were, respectively, included in post-2nd dose and post-3rd dose immunogenicity evaluations conducted on a per protocol basis. After two and three PCV7 vaccinations, 63.0-98.0 and 97.2-100% of infants achieved an antibody level of >or=0.35microg/mL, respectively, with a lowest against serotype 6B. No vaccination-related serious adverse reactions were observed. Thus, PCV7 appears safe and highly immunogenic in Korean infants, and adopting two doses for a primary series could be a feasible option for facilitating vaccine coverage rate.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAntibody Formation/*immunologyen
dc.subjectAsiaen
dc.subjectDose-Response Relationship, Immunologicen
dc.subjectHumansen
dc.subjectImmunizationen
dc.subjectInfanten
dc.subjectKorea/epidemiologyen
dc.subjectMeningococcal Vaccines/administration & dosage/adverse effects/*immunologyen
dc.subjectPneumococcal Vaccines/administration & dosage/adverse effects/*immunologyen
dc.subject*Safetyen
dc.subjectVaccines, Combined/adverse effects/immunologyen
dc.subjectVaccines, Conjugate/*administration & dosage/*immunologyen
dc.titleImmunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian childrenen
dc.typeArticleen
dc.contributor.AlternativeAuthor김남희-
dc.contributor.AlternativeAuthor이진아-
dc.contributor.AlternativeAuthor이상정-
dc.contributor.AlternativeAuthor이현주-
dc.contributor.AlternativeAuthor김경효-
dc.contributor.AlternativeAuthor박수은-
dc.contributor.AlternativeAuthor이환종-
dc.identifier.doi10.1016/j.vaccine.2007.08.022-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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