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Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Nam-Hee | - |
dc.contributor.author | Lee, Jina | - |
dc.contributor.author | Lee, Sang Jeong | - |
dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Kim, Kyung-Hyo | - |
dc.contributor.author | Park, Su-Eun | - |
dc.contributor.author | Lee, Hoan-Jong | - |
dc.date.accessioned | 2009-12-30T02:03:09Z | - |
dc.date.available | 2009-12-30T02:03:09Z | - |
dc.date.issued | 2007-10-13 | - |
dc.identifier.citation | Vaccine 2007;25(45):7858-65 | en |
dc.identifier.issn | 0264-410X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17931753 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23423 | - |
dc.description.abstract | This study was conducted to determine the immunogenicity and safety of a 7-valent CRM197 protein conjugated pneumococcal vaccine (PCV7) in Korean infants immunized at 2, 4 and 6 months. A total of 202 infants were enrolled and 146 and 141 infants were, respectively, included in post-2nd dose and post-3rd dose immunogenicity evaluations conducted on a per protocol basis. After two and three PCV7 vaccinations, 63.0-98.0 and 97.2-100% of infants achieved an antibody level of >or=0.35microg/mL, respectively, with a lowest against serotype 6B. No vaccination-related serious adverse reactions were observed. Thus, PCV7 appears safe and highly immunogenic in Korean infants, and adopting two doses for a primary series could be a feasible option for facilitating vaccine coverage rate. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Antibody Formation/*immunology | en |
dc.subject | Asia | en |
dc.subject | Dose-Response Relationship, Immunologic | en |
dc.subject | Humans | en |
dc.subject | Immunization | en |
dc.subject | Infant | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Meningococcal Vaccines/administration & dosage/adverse effects/*immunology | en |
dc.subject | Pneumococcal Vaccines/administration & dosage/adverse effects/*immunology | en |
dc.subject | Vaccines, Combined/adverse effects/immunology | en |
dc.subject | Vaccines, Conjugate/*administration & dosage/*immunology | en |
dc.subject | Safety | - |
dc.title | Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김남희 | - |
dc.contributor.AlternativeAuthor | 이진아 | - |
dc.contributor.AlternativeAuthor | 이상정 | - |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 김경효 | - |
dc.contributor.AlternativeAuthor | 박수은 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.identifier.doi | 10.1016/j.vaccine.2007.08.022 | - |
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