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NOX4 as an oxygen sensor to regulate TASK-1 activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young-Mee | - |
dc.contributor.author | Kim, Byung-Joo | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Choi, Hyunsung | - |
dc.contributor.author | Kim, Myung-Suk | - |
dc.contributor.author | Park, Jong-Wan | - |
dc.date.accessioned | 2009-12-30T02:27:35Z | - |
dc.date.available | 2009-12-30T02:27:35Z | - |
dc.date.issued | 2006-07-16 | - |
dc.identifier.citation | Cell Signal. 2006 Apr;18(4):499-507. Epub 2005 Jul 14. | en |
dc.identifier.issn | 0898-6568 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16019190 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23437 | - |
dc.description.abstract | When oxygen sensing cells are excited by hypoxia, background K+ currents are inhibited. TASK-1, which is commonly expressed in oxygen sensing cells and makes a background K+ current, is inactivated by hypoxia. Thus TASK-1 is a candidate molecule responsible for hypoxic excitation. However, TASK-1 per se cannot sense oxygen and may require a regulatory protein that can. In the present study, we propose that the NADPH oxidase NOX4 functions as an oxygen-sensing partner and that it modulates the oxygen sensitivity of TASK-1. Confocal imaging revealed the co-localization of TASK-1 and NOX4 in the plasma membrane. In HEK293 cells expressing NOX4 endogenously, the activity of expressed TASK-1 was moderately inhibited by hypoxia, and this oxygen response was significantly augmented by NOX4. Moreover, the oxygen sensitivity of TASK-1 was abolished by NOX4 siRNA and NADPH oxidase inhibitors. These results suggest a novel function for NOX4 in the oxygen-dependent regulation of TASK-1 activity. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Anoxia/metabolism | en |
dc.subject | Biosensing Techniques/*methods | en |
dc.subject | Cell Line | en |
dc.subject | Cell Membrane/metabolism | en |
dc.subject | Enzyme Inhibitors/pharmacology | en |
dc.subject | Humans | en |
dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit/drug effects/metabolism | en |
dc.subject | NADPH Oxidase/antagonists & inhibitors/genetics/*physiology | en |
dc.subject | Nerve Tissue Proteins | en |
dc.subject | Onium Compounds/pharmacology | en |
dc.subject | Oxygen/analysis/*metabolism | en |
dc.subject | Potassium/metabolism/physiology | en |
dc.subject | Potassium Channels, Tandem Pore Domain/antagonists & | en |
dc.subject | inhibitors/*metabolism | en |
dc.subject | RNA, Small Interfering/genetics/pharmacology/physiology | en |
dc.subject | Signal Transduction/drug effects/physiology | en |
dc.title | NOX4 as an oxygen sensor to regulate TASK-1 activity | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이영미 | - |
dc.contributor.AlternativeAuthor | 김병주 | - |
dc.contributor.AlternativeAuthor | 전양숙 | - |
dc.contributor.AlternativeAuthor | 서인석 | - |
dc.contributor.AlternativeAuthor | 최현성 | - |
dc.contributor.AlternativeAuthor | 김명석 | - |
dc.contributor.AlternativeAuthor | 박종완 | - |
dc.identifier.doi | 10.1016/j.cellsig.2005.05.025 | - |
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