S-Space College of Medicine/School of Medicine (의과대학/대학원) Program in Clinical Pharmacology (협동과정-임상약리학전공) Journal Papers (저널논문_협동과정-임상약리학전공)
Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder
- Kim, Myung-Sun; Kim, Young Youn; Yoo, So Young; Kwon, Jun Soo
- Issue Date
- Depress Anxiety 24:22-31
- Adult; Brain Mapping; Cerebral Cortex/*physiopathology; Discrimination (Psychology)/physiology; Dominance, Cerebral/physiology; *Electroencephalography; Event-Related Potentials, P300/physiology; Female; Frontal Lobe/physiopathology; Functional Laterality/physiology; Humans; *Inhibition (Psychology); Male; Nerve Net/physiopathology; Obsessive-Compulsive Disorder/*physiopathology/psychology; Pattern Recognition, Visual/physiology; Psychomotor Performance/*physiology; Reaction Time/physiology; *Signal Processing, Computer-Assisted; Statistics as Topic
- In this study, we have attempted to determine the electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder (OCD). To evaluate response inhibition ability, we have used the Go/NoGo task and measured N2 and P3 event-related potential (ERP) components. Both the OCD and control groups exhibited greater and more frontally distributed N2 and P3 amplitudes in the NoGo condition compared to what we observed in the Go condition. However, the patients with OCD also manifested reduced NoGo-N2 and Go-N2 amplitudes at the frontocentral electrode sites compared to the controls. In addition, the NoGo-N2 amplitudes were more posteriorly distributed in patients with OCD than in controls. The NoGo-N2 amplitudes and latencies measured at the central sites were also negatively correlated with the obsession score on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The OCD and control groups were comparable with regard to Go-P3 and NoGo-P3 amplitude and latencies. Our findings suggest dysfunctions in frontal regions mediating response inhibition in OCD, consistent with the involvement of response inhibition in the pathophysiology of this disorder. In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3.
- 1091-4269 (Print)
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