Publications
Detailed Information
SPP1 polymorphisms associated with HBV clearance and HCC occurrence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.date.accessioned | 2009-12-30T06:36:04Z | - |
dc.date.available | 2009-12-30T06:36:04Z | - |
dc.date.issued | 2007-05-15 | - |
dc.identifier.citation | Int J Epidemiol 2007;36:1001-8 | en |
dc.identifier.issn | 0300-5771 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17496055 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23627 | - |
dc.description.abstract | BACKGROUND: Secreted phosphoprotein-1 (SPP1) is a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein. SPP1 is overexpressed in metastatic hepatocellular carcinoma (HCC), and therefore could act as both a diagnostic marker and a potential therapeutic target for metastatic HCC. We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic study of hepatitis B virus (HBV) clearance and HCC occurrence. METHODS: Five genetic variants in SPP1 were genotyped by TaqMan assay and the genetic association with HBV clearance and HCC occurrence was analysed. RESULTS: Genetic association analysis of SPP1 polymorphisms with an HBV cohort (n = 1,069) from the Korean population revealed that the most common haplotype (SPP1-ht2 [T-T-C-T-A]) was associated with HBV clearance. The frequency of the SPP1-ht2-bearing genotype in the chronic carrier (CC) group was higher than in the spontaneously recovered (SR) group (OR = 1.44 [95% CI 1.11-1.87], P = 0.006, P(corr) = 0.02). By Cox relative hazard analysis, both SPP1-ht2 and -1,800G > T were associated with age of HCC occurrence among chronic hepatitis patients, e.g. ht2/h2- and 1800T/T-bearing patients showed earlier progression to HCC than did others (RH = 1.85, P = 0.004, P(corr) = 0.01 and RH = 1.85, P = 0.003, P(corr) = 0.01, respectively). CONCLUSION: Our findings suggest that SPP1 polymorphisms might be among the genetic factors for HBV clearance and/or HCC occurrence. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | Age of Onset | en |
dc.subject | Carcinoma, Hepatocellular/*genetics/virology | en |
dc.subject | Chromosome Mapping | en |
dc.subject | Disease Progression | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes | en |
dc.subject | Hepatitis B virus/isolation & purification | en |
dc.subject | Hepatitis B, Chronic/complications/*genetics/virology | en |
dc.subject | Humans | en |
dc.subject | Liver Neoplasms/*genetics/virology | en |
dc.subject | Logistic Models | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Osteopontin/*genetics | en |
dc.subject | Prospective Studies | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | SPP1 polymorphisms associated with HBV clearance and HCC occurrence | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 정현섭 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.1093/ije/dym093 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.