Browse

Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations

Cited 161 time in Web of Science Cited 183 time in Scopus
Authors
Myrand, S. P.; Sekiguchi, K.; Man, M. Z.; Lin, X.; Tzeng, R. Y.; Teng, C. H.; Hee, B.; Garrett, M.; Kikkawa, H.; Lin, C. Y.; Eddy, S. M.; Dostalik, J.; Mount, J.; Azuma, J.; Fujio, Y.; Jang, I. J.; Shin, S. G.; Bleavins, M. R.; Williams, J. A.; Paulauskis, J. D.; Wilner, K. D.
Issue Date
2008-01-31
Publisher
Elsevier
Citation
Clin Pharmacol Ther. 2008 Sep;84(3):347-61. Epub 2008 Mar 19.
Keywords
AllelesClinical Trials, Phase III as TopicCytochrome P-450 Enzyme System/blood/*genetics/metabolismEuropean Continental Ancestry Group/geneticsFar East*Genetics, Population*GenotypeHumansJapanMulticenter Studies as Topic*Pharmacokinetics
Abstract
Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors influencing responsible pharmacokinetic/pharmacogenomic approaches could facilitate the universal application of foreign data and reduce the total amount of phase III clinical trials evaluating risks in different populations. Our objective was to establish and compare genotype (major cytochrome P450 (CYP) enzymes)/phenotype associations for Japanese (native and first- and third-generation Japanese living abroad), Caucasian, Chinese, and Korean populations using a standard drug panel. The mean metabolic ratios (MRs) for the four ethnic groups were similar except for a lower activity of CYP2D6 in Caucasians and CYP2C19 in Asians. Genotype, not ethnicity, impacted the MR for CYP2C9, CYP2C19, and CYP2D6; neither affected CYP1A2, CYP2E1, and CYP3A4/5 activities. We conclude that equivalent plasma drug concentrations and metabolic profiles can be expected for native Japanese, first- and third-generation Japanese, Koreans, and Chinese for compounds handled through these six CYP enzymes.
ISSN
1532-6535 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18231117

https://hdl.handle.net/10371/23838
DOI
https://doi.org/10.1038/sj.clpt.6100482
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse