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One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Lan, Qing | - |
dc.contributor.author | Kricker, Anne | - |
dc.contributor.author | Purdue, Mark P. | - |
dc.contributor.author | Grulich, Andrew E. | - |
dc.contributor.author | Vajdic, Claire M. | - |
dc.contributor.author | Turner, Jennifer | - |
dc.contributor.author | Whitby, Denise | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Chanock, Stephen | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Armstrong, Bruce K. | - |
dc.date.accessioned | 2009-12-31T01:26:54Z | - |
dc.date.available | 2009-12-31T01:26:54Z | - |
dc.date.issued | 2007-09-25 | - |
dc.identifier.citation | Hum Genet. 2007 Dec;122(5):525-33. Epub 2007 Sep 21. | en |
dc.identifier.issn | 1432-1203 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17891500 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23893 | - |
dc.description.abstract | Dysregulation of the one-carbon metabolic pathway, which controls nucleotide synthesis and DNA methylation, may promote lymphomagenesis. We evaluated the association between polymorphisms in one-carbon metabolism genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study in Australia. Cases (n = 561) and controls (n = 506) were genotyped for 14 selected single-nucleotide polymorphisms in 10 genes (CBS, FPGS, FTHFD, MTHFR, MTHFS, MTR, SHMT1, SLC19A1, TCN1, and TYMS). We also conducted a meta-analysis of all studies of Caucasian populations investigating the association between MTHFR Ex5+79C > T (a.k.a., 677C>T) and NHL risk. A global test of 13 genotypes was statistically significant for diffuse large B-cell lymphoma (DLBCL; P = 0.008), but not for follicular lymphoma (FL; P = 0.27) or all NHL (P = 0.17). The T allele at MTHFR Ex5+79 was marginally significantly associated with all NHL (OR = 1.25, 95% CI = 0.98-1.59) and DLBCL (1.36, 0.96-1.93). The T allele at TYMS Ex8+157 was associated with a reduced risk of FL (0.64, 0.46-0.91). An elevated risk of NHL was also observed among carriers of the G allele at FTHFD Ex21+31 (all NHL, 1.31, 1.02-1.69; DLBCL, 1.50, 1.05-2.14). A meta-analysis of 11 studies conducted in Caucasian populations of European origin (4,121 cases and 5,358 controls) supported an association between the MTHFR Ex5+79 T allele and increased NHL risk (additive model, P = 0.01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Australia | en |
dc.subject | Carbon/*metabolism | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Lymphoma, B-Cell/etiology/genetics/metabolism | en |
dc.subject | Lymphoma, Non-Hodgkin/etiology/*genetics/*metabolism | en |
dc.subject | Lymphoma, T-Cell/etiology/genetics/metabolism | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Models, Biological | en |
dc.subject | Risk Factors | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s00439-007-0431-2 | - |
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