S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Subjective response to clozapine and risperidone treatment in outpatients with schizophrenia
- Issue Date
- Prog Neuropsychopharmacol Biol Psychiatry. 2006 Mar;30(2):301-5. Epub 2005 Nov 23.
- Adult ; Antipsychotic Agents/*therapeutic use ; Attitude ; Chi-Square Distribution ; Clozapine/*therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Multivariate Analysis ; Outpatients/*psychology ; Psychiatric Status Rating Scales ; Questionnaires ; Risperidone/*therapeutic use ; Schizophrenia/*drug therapy ; Time Factors ; Schizophrenic Psychology
- The purpose of the present study was to compare the subjective response and attitude towards antipsychotic treatment between schizophrenic patients receiving clozapine and those receiving risperidone. Ninety-four outpatients who had been on a stable drug dosage were evaluated (clozapine group: n=57, mean dose=254.1 mg/day; risperidone group: n=37, mean dose=3.0 mg/day). Subjective response to antipsychotic treatment was assessed using the Drug Attitude Inventory (DAI). The two treatment groups had a positive total mean score, indicating that both groups had a positive subjective view of drug treatment. The proportion of subjects who had a positive total score was not different between the two groups. In subscale scores, multivariate analysis revealed that clozapine group tended to have a higher score on the subjective positive response subscale (P=0.06). The scores of subjective negative response or attitude to medication subscales were not different between groups. In conclusion, there was no marked difference between stabilized outpatients taking clozapine and risperidone in terms of subjective response and attitude towards antipsychotic treatment. Considering that subjects treated with clozapine were treatment resistant patients, equal DAI score might indicate a more favorable subjective experience of clozapine. Further prospective studies on subjective response to various atypical agents are required to obtain valuable insight into how best to use these drugs from the patient's perspective.
- 0278-5846 (Print)
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