Browse

Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in young children with asthma: their relationship with blood eosinophils and serum eosinophil cationic protein

Cited 22 time in Web of Science Cited 25 time in Scopus
Authors
Choi, S H; Kim, D K; Yu, J; Yoo, Y; Koh, Y Y
Issue Date
2007-06-19
Publisher
Wiley-Blackwell
Citation
Allergy. 2007 Oct;62(10):1119-24. Epub 2007 Jun 16.
Keywords
Adenosine Monophosphate/*diagnostic use/immunologyAsthma/*diagnosis/*immunologyBronchial Hyperreactivity/diagnosis/immunologyBronchial Provocation TestsBronchitis/diagnosis/immunologyChildChild, PreschoolEosinophil Cationic Protein/*blood/immunologyEosinophils/enzymology/*immunologyFemaleHumansHypersensitivity, Immediate/blood/immunologyMaleMethacholine Chloride/*diagnostic use/immunology
Abstract
BACKGROUND: Bronchial hyperresponsiveness is a characteristic feature of asthma, and is usually measured by bronchial challenges using direct or indirect stimuli. Blood eosinophil numbers and serum levels of eosinophil cationic protein (ECP) are considered as indirect measures of airway inflammation in asthma. The aim of this study was to investigate whether bronchial responsiveness to adenosine 5'-monophosphate (AMP) is more closely associated with blood eosinophil markers, compared with that to methacholine, in young children with asthma. METHODS: Methacholine and AMP bronchial challenges were performed in 4- to 6-year-old children with asthma (n = 77) and in healthy controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. The peripheral blood eosinophil counts and serum ECP concentrations were determined in each subject. RESULTS: A positive response to methacholine (end-point concentration < or =8mg/ml) and to AMP (end-point concentration < or =200 mg/ml) was observed in 74 (96.1%) and 66 asthmatic children (85.7%), respectively. A majority of controls was unresponsive to both challenges. In the asthma group, there was no significant correlation between methacholine end-point concentration and the eosinophil counts (r = -0.111, P = 0.337) or serum ECP levels (r = -0.126, P = 0.274). In contrast, AMP end-point concentration correlated significantly with the eosinophil counts (r = -0.372, P = 0.001) and with serum ECP levels (r = -0.371, P = 0.001). CONCLUSIONS: Our results suggest that bronchial responsiveness to AMP is more closely related to airway inflammation, compared with that to methacholine, and support the potential usefulness of AMP challenges in detecting inflammatory changes in young children with asthma.
ISSN
0105-4538 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17573858

https://hdl.handle.net/10371/24291
DOI
https://doi.org/10.1111/j.1398-9995.2007.01412.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse