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Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jun Mo | - |
dc.contributor.author | Park, Hi Joon | - |
dc.contributor.author | Choi, Yeong Gon | - |
dc.contributor.author | Choe, Il Hwan | - |
dc.contributor.author | Park, Jae Hyun | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Lim, Sabina | - |
dc.date.accessioned | 2009-12-31T04:34:16Z | - |
dc.date.available | 2009-12-31T04:34:16Z | - |
dc.date.issued | 2006-12-19 | - |
dc.identifier.citation | Brain Res. 2007 Feb 2;1131(1):211-9. Epub 2006 Dec 14. | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17173870 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24299 | - |
dc.description.abstract | Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) for 5 consecutive days. Acupuncture was then applied to acupoints Yanglingquan (GB34) and Taichong (LR3) starting 2 h after the first MPTP administration and then at 48 h intervals until the mice were sacrificed for analyses at 1, 3, and 7 days after the last MPTP injection. These experiments demonstrated that acupuncture inhibited the decreased of the tyrosine hydroxylase (TH) immunoreactivity (IR) and generated a neuroprotective effects in the striatum (ST) and the substantia nigra (SN) on days 1, 3, and 7 post-MPTP injections. Acupuncture attenuated the increase of macrophage antigen complex-1 (MAC-1), a marker of microglial activation, at 1 and 3 days and reduced the increases in cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression on days 1, 3, and 7. In MPTP group, striatal dopamine (DA) was measured by 46% at 7 days, whereas DA in the acupuncture group was 78%. On the basis of these results, we suggest that acupuncture could be used as a neuroprotective intervention for the purpose of inhibiting microglial activation and inflammatory events in PD. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Acupuncture/*methods/trends | en |
dc.subject | Animals | en |
dc.subject | Biological Markers/metabolism | en |
dc.subject | Corpus Striatum/metabolism/physiopathology | en |
dc.subject | Cyclooxygenase 2/metabolism | en |
dc.subject | Cytoprotection/*physiology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Dopamine/biosynthesis | en |
dc.subject | Encephalitis/chemically induced/prevention & control/*therapy | en |
dc.subject | Gliosis/chemically induced/prevention & control/*therapy | en |
dc.subject | Macrophage-1 Antigen/metabolism | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Microglia/drug effects/*physiology | en |
dc.subject | Nitric Oxide Synthase Type II/metabolism | en |
dc.subject | Parkinsonian Disorders/physiopathology/prevention & control/*therapy | en |
dc.subject | Substantia Nigra/metabolism/physiopathology | en |
dc.subject | Treatment Outcome | en |
dc.subject | Tyrosine 3-Monooxygenase/metabolism | en |
dc.subject | Up-Regulation/physiology | en |
dc.title | Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강준모 | - |
dc.contributor.AlternativeAuthor | 박히준 | - |
dc.contributor.AlternativeAuthor | 최영곤 | - |
dc.contributor.AlternativeAuthor | 최일환 | - |
dc.contributor.AlternativeAuthor | 박재현 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.contributor.AlternativeAuthor | 임사비나 | - |
dc.identifier.doi | 10.1016/j.brainres.2006.10.089 | - |
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