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Genetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virus

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dc.contributor.authorKim, Yun-Kyung-
dc.contributor.authorChoi, Eun-Hwa-
dc.contributor.authorLee, Hoan-Jong-
dc.date.accessioned2009-12-31T05:03:58Z-
dc.date.available2009-12-31T05:03:58Z-
dc.date.issued2007-04-26-
dc.identifier.citationJ Med Virol. 2007 Jun;79(6):820-8.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17457915-
dc.identifier.urihttps://hdl.handle.net/10371/24380-
dc.description.abstractAlthough antigenic and genetic variations were shown to occur both in the G and F protein of respiratory syncytial virus (RSV), few studies looked at the variation of F gene. The F genotypes were determined by the evaluation of clustering patterns, via the phylogenetic analysis of the nucleotide sequences of a variable region in the F gene. One hundred seventy-nine strains obtained from a children's hospital in Korea over nine consecutive epidemics were included. The relationship between the F and G genotypes was analyzed with the G genotypes previously published by the authors. The phylogenetic analysis of the variable region from the F gene revealed 9 genotypes among 129 group A RSVs and 4 genotypes among 50 group B RSVs. In each of the epidemics, the dominant genotypes were replaced with new genotypes in consecutive epidemics. In each of the epidemics of group B RSVs, the predominant genotype alternated between genotypes. Most of the strains which clustered to a particular F genotype were assigned to particular G genotype(s). By determining the nearly entire sequences of the F genes, we revealed the percentage of the nucleotide differences which resulted in amino acid coding changes was determined to be much great in two distinct variable regions of the F gene. Our results indicated that the F gene of the RSVs may be continuously evolving under selective pressure in a distinct pattern, and that the genetic variability of the F protein is associated with that of the G protein.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdolescenten
dc.subjectAmino Acid Substitutionen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectEvolution, Molecularen
dc.subject*Genetic Variationen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectKorea/epidemiologyen
dc.subjectMutationen
dc.subjectPhylogenyen
dc.subjectRNA, Viral/geneticsen
dc.subjectRespiratory Syncytial Virus Infections/epidemiology/*virologyen
dc.subjectRespiratory Syncytial Viruses/*classification/*genetics/isolation &en
dc.subjectpurificationen
dc.subjectSequence Analysis, DNAen
dc.subjectSequence Homologyen
dc.subjectViral Fusion Proteins/*geneticsen
dc.titleGenetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virusen
dc.typeArticleen
dc.contributor.AlternativeAuthor김연경-
dc.contributor.AlternativeAuthor최은화-
dc.contributor.AlternativeAuthor이환종-
dc.identifier.doi10.1002/jmv.20891-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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