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Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder

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dc.contributor.authorKim, Minue J-
dc.contributor.authorChey, Jeanyung-
dc.contributor.authorChung, Ain-
dc.contributor.authorBae, Soojeong-
dc.contributor.authorKhang, Hyunsoo-
dc.contributor.authorHam, Byungjoo-
dc.contributor.authorYoon, Sujung J-
dc.contributor.authorJeong, Do-Un-
dc.contributor.authorLyoo, In Kyoon-
dc.date.accessioned2009-12-31T05:18:37Z-
dc.date.available2009-12-31T05:18:37Z-
dc.date.issued2007-04-03-
dc.identifier.citationJ Psychiatr Res. 2008 Mar;42(4):268-77. Epub 2007 Apr 2.en
dc.identifier.issn0022-3956 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17400251-
dc.identifier.urihttp://hdl.handle.net/10371/24433-
dc.description.abstractBACKGROUND: Previous brain imaging studies have reported hyperactivation of the amygdala and hypoactivation of the anterior cingulate in posttraumatic stress disorder (PTSD) patients, which is believed to be an underlying neural mechanism of the PTSD symptoms. The current study specifically focuses on the abnormal activity of the rostral anterior cingulate, using a paradigm which elicits an unexpected processing conflict caused by salient emotional stimuli. METHODS: Twelve survivors (seven men and five women) of the Taegu subway fire in 2003, who later developed PTSD, agreed to participate in this study. Twelve healthy volunteers (seven men and five women) were recruited for comparison. Functional brain images of all participants were acquired using functional magnetic resonance imaging while performing a same-different judgment task, which was modified to elicit an unexpected emotional processing conflict. RESULTS: PTSD patients, compared to comparison subjects, showed a decreased rostral anterior cingulate functioning when exposed to situations which induce an unexpected emotional processing conflict. Moreover, PTSD symptom severity was negatively correlated to the level of decrease in the rostral anterior cingulate activity. CONCLUSIONS: The results of this study provide evidence that the rostral anterior cingulate functioning is impaired in PTSD patients during response-conflict situations that involve emotional stimuli.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAffecten
dc.subjectCerebrovascular Circulation/physiologyen
dc.subjectConflict (Psychology)en
dc.subjectDiagnostic and Statistical Manual of Mental Disordersen
dc.subjectFemaleen
dc.subjectGyrus Cinguli/*blood supply/*physiopathologyen
dc.subjectHumansen
dc.subject*Life Change Eventsen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPositron-Emission Tomographyen
dc.subjectQuestionnairesen
dc.subjectSeverity of Illness Indexen
dc.subjectStress Disorders, Post-Traumatic/diagnosis/*physiopathologyen
dc.titleDiminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorderen
dc.typeArticleen
dc.contributor.AlternativeAuthor김민유-
dc.contributor.AlternativeAuthor최진영-
dc.contributor.AlternativeAuthor정아인-
dc.contributor.AlternativeAuthor배수정-
dc.contributor.AlternativeAuthor강현수-
dc.contributor.AlternativeAuthor함병주-
dc.contributor.AlternativeAuthor윤수정-
dc.contributor.AlternativeAuthor정도언-
dc.contributor.AlternativeAuthor류인균-
dc.identifier.doi10.1016/j.jpsychires.2007.02.003-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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